Results 101 to 110 of about 192,514 (206)

mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses

Viruses
Vaccination has led to significant dismantling of infectious diseases worldwide. Since the dawn of the SARS-CoV-2 pandemic, there has been increased popularity in the usage and study of the mRNA vaccine platform.
Janan Shoja Doost, Fatemeh Fazel, Nitish Boodhoo, Shayan Sharif   +3 more
doaj   +1 more source

Development of a novel-ionizable-lipid-based mRNA vaccine for broad protection against Streptococcus pneumoniae

Molecular Therapy: Nucleic Acids
Recently, messenger RNA (mRNA)-based vaccine technology has made significant advances in preventing pathogenic microbial infections. The composition and physicochemical properties of lipid nanoparticle (LNP) determine the delivery efficiency of mRNA ...
Shi Xu, Guoqing Qi, Rui Liu, Shang Liu, Aili Wang, Wei Li, Keyue Ruan, Lingzhi Zhan, Lianshun Wang, Caiyi Fei, Jiyang Zhao, Xue Zhang, Qin Yu, Mengwei Xu, Jing Li, Tiyun Han   +15 more
doaj   +1 more source

Impact of B18R-Encoding Messenger Ribonucleic Acid Co-Delivery on Neutralizing Antibody Production in Self-Amplifying Messenger Ribonucleic Acid Vaccines

Vaccines
Objectives: The COVID-19 pandemic has brought mRNA vaccines to the forefront due to their widespread use. In this study, we explored the potential advantages of the self-amplifying mRNA (saRNA) vaccine over conventional mRNA vaccines. Methods: Initially,
Yutao Wang, Lei Li, Min Liang, Gan Liu, Yinying Lu   +4 more
doaj   +1 more source

HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers [PDF]

, 2010
The search for novel tumour antigens that are either uniquely expressed or over-expressed in a wide variety of tumours is still ongoing. Because of their expression in a broad spectrum of cancers and limited expression in normal tissues, cancer/testis ...
Badoual, C, Linley, AJ, Mathieu, MG, McArdle, SEB, Reeder, SP, Rees, RC, Tartour, E   +6 more
core  

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy [PDF]

, 2014
Breckpot, Karine, De Smedt, Stefaan, Dewitte, Heleen, Heirman, Carlo, Lentacker, Ine, Thielemans, Kris, Van Lint, Sandra   +6 more
core   +1 more source

mRNA vaccine designs for optimal adjuvanticity and delivery

RNA Biology
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the co-delivery of antigen mRNA and adjuvants in a unified, all-in-one formulation.
Yuki Mochida, Satoshi Uchida
doaj   +1 more source

Lipid nanoparticle-delivered mRNA vaccine encoding the MOMP of Chlamydia psittaci elicits protective immune responses in BALB/c mice

Microbiology Spectrum
Chlamydia psittaci is an important pathogenic zoonotic pathogen that infects birds and can be transmitted to humans and other animals. This research focused on creating an mRNA vaccine targeting C.
Buwei Wang, Jian Xiao, Jiewen Wang, Wanying Zhang, Yinqi Jin, Yalan Jiang, Yuqing Chen, Zhangping He, Aihua Lei, Chunxue Lu, Chuan Wang   +10 more
doaj   +1 more source

Preventing COVID-19 in at-risk populations: moving toward next-generation mRNA-1283 COVID-19 vaccine to address current challenges

Expert Review of Vaccines
Introduction Next-generation COVID-19 vaccines hold promise to reduce severe outcomes in populations most at risk. While the original mRNA COVID-19 vaccine, mRNA-1273, targets the full-length SARS-CoV-2 spike protein, mRNA-1283 is a novel next-generation
Joseph B. Domachowske, Gregory D. Zimet, William Hanage, Ekkehard Beck, Preeti Sule, Rahnuma Wahid, Nevena Vicic   +6 more
doaj   +1 more source

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site

Nature Communications
mRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of mRNA vaccines by generating a comprehensive single-cell transcriptome ...
Seongryong Kim, Ji Hyang Jeon, Myeonghwan Kim, Yeji Lee, Yun-Ho Hwang, Myungsun Park, C. Han Li, Taeyoung Lee, Jung-Ah Lee, You-Me Kim, Dokeun Kim, Hyukjin Lee, You-Jin Kim, V. Narry Kim, Jong-Eun Park, Jinah Yeo   +15 more
doaj   +1 more source

Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters.

PLoS ONE
In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations.
Theodoros V Giannouchos, Nicole L Hair, Bankole Olatosi, Xiaoming Li   +3 more
doaj   +1 more source