Results 81 to 90 of about 1,693,659 (204)

The Delivery of mRNA Vaccines for Therapeutics

Life, 2022
mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered
Nitika, Jiao Wei, Ai-Min Hui
openaire   +3 more sources

An mRNA vaccine provides effective protection against Duck Tembusu Virus infection

npj Vaccines
As an emerging flavivirus, Duck Tembusu virus (DTMUV) causes severe neurological disorder and acute egg drop syndrome in poultry. Herein, we report the development of a highly effective mRNA vaccine against DTMUV using lipid nanoparticle (LNP) delivery ...
Shi Xu, Lijiao Zhang, Caiyi Fei, Guilai Liu, Mengwei Xu, Rui Liu, Jing Li, Aili Wang, Qing He, Ke Cai, Qingtao Liu, Tiyun Han   +11 more
doaj   +1 more source

Varicella zoster virus mRNA vaccine candidate induced superior cellular immunity and comparable humoral and Fc-mediated immunity compared to the licensed subunit vaccine in a mouse model

Human Vaccines & Immunotherapeutics
The threat of herpes zoster (HZ) is increasing, particularly in the elderly and immunocompromised individuals. Although two platform vaccines are currently available for HZ prevention, the low effectiveness of the live attenuated varicella-zoster virus ...
Eun-Jeong Jang, Sivilay Xayaheuang, Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Seok-Tae Choi, Hye Won Kwak, Jae-Hwan Nam, Keunea Kim, Boomi Yoon, Jae Hyang Lim, Ho Seong Seo, Chang-Hoon Woo, Hosun Park   +13 more
doaj   +1 more source

Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans

medRxiv
Lipid nanoparticle mRNA vaccines are an exciting but new technology used in humans. There is limited understanding of factors that influence their biodistribution and immunogenicity. Antibodies to polyethylene glycol (PEG), which is on the surface of the
S. Kent, Shiyao Li, T. Amarasena, A. Reynaldi, W. Lee, M. Leeming, D. H. O’Connor, Julie Nguyen, H. Kent, Frank Caruso, J. Juno, A. Wheatley, Miles P. Davenport, Yi Ju   +13 more
semanticscholar   +1 more source

An Mpox Multi-Antigen-Tandem Bivalent mRNA Candidate Vaccine Effectively Protects Mice Against the Vaccinia Virus

Vaccines
Background: Since the outbreak of mpox in 2022, the disease has spread rapidly worldwide and garnered significant public attention. Vaccination is regarded as an effective measure to prevent the spread of mpox.
Jun Zuo, Jiayu Wu, Zhen Zhang, Jinrong Long, Changxiao Yu, Yuqin Liao, Hongsheng Zhang, Jing Yang   +7 more
doaj   +1 more source

Long-term stability and immunogenicity of lipid nanoparticle COVID-19 mRNA vaccine is affected by particle size

Human Vaccines & Immunotherapeutics
Messenger ribonucleic acid (mRNA) technology has been rapidly applied for the development of the COVID-19 vaccine. However, naked mRNA itself is inherently unstable. Lipid nanoparticles (LNPs) protect mRNAs from extracellular ribonucleases and facilitate
Ruimeng Shi, Xueli Liu, Yajuan Wang, Meilu Pan, Shaoqing Wang, Lin Shi, Beibei Ni   +6 more
semanticscholar   +1 more source

Trans amplifying mRNA vaccine expressing consensus spike elicits broad neutralization of SARS CoV 2 variants

npj Vaccines
SARS-CoV-2 continues to evolve and evade vaccine immunity necessitating vaccines that offer broad protection across variants. Conventional mRNA vaccines face cost and scalability challenges, prompting the exploration of alternative platforms like trans ...
Abhinay Gontu, Sougat Misra, Shubhada K. Chothe, Santhamani Ramasamy, Padmaja Jakka, Maurice Byukusenge, Lindsey C. LaBella, Meera Surendran Nair, Bhushan M. Jayarao, Marco Archetti, Ruth H. Nissly, Suresh V. Kuchipudi   +11 more
doaj   +1 more source

A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety

Bioactive Materials
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control of the COVID-19 pandemic.
Seo-Hyeon Bae, Soyeon Yoo, Jisun Lee, Hyo‐Jung Park, S. Kwon, Harin Jin, Sang-In Park, Yu-Sun Lee, Yoo-Jin Bang, Gahyun Roh, Seonghyun Lee, S. Youn, In Woo Kim, Ho Rim Oh, Ashraf K. El-Damasy, G. Keum, Hojun Kim, H. Youn, Jae-Hwan Nam, Eun‐Kyoung Bang   +19 more
semanticscholar   +1 more source

mRNA vaccines: a new era in vaccine development

Oncology Research
The advent of RNA therapy, particularly through the development of mRNA cancer vaccines, has ushered in a new era in the field of oncology. This article provides a concise overview of the key principles, recent advancements, and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer treatment.
Chandra, Shubhra, Wilson, Jennifer C, Good, David, Wei, Ming Q   +3 more
openaire   +4 more sources

Immunogenicity of HIV-1 Env mRNA and Env-Gag VLP mRNA Vaccines in Mice

Vaccines
Background: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic. Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins.
Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng   +5 more
doaj   +1 more source