Results 31 to 40 of about 1,693,659 (204)

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Nature, 2021
The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown.
P. Arunachalam, Madeleine K. D. Scott, T. Hagan, Chunfeng Li, Yupeng Feng, F. Wimmers, Lilit Grigoryan, M. Trisal, V. Edara, L. Lai, S. Chang, A. Feng, Shaurya Dhingra, Mihir M. Shah, Alexandra S. Lee, S. Chinthrajah, S. Sindher, V. Mallajosyula, Fei Gao, Natalia Sigal, S. Kowli, Sheena Gupta, K. Pellegrini, G. Tharp, Sofia Maysel-Auslender, Sydney Hamilton, H. Aoued, K. Hrusovsky, M. Roskey, S. Bosinger, H. Maecker, S. Boyd, Mark M. Davis, P. Utz, M. Suthar, P. Khatri, K. Nadeau, B. Pulendran   +37 more
semanticscholar   +1 more source

From mRNA sensing to vaccines [PDF]

Immunity, 2021
The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
Fauci, Anthony S., Merad, Miriam, Swaminathan, Soumya, Hur, Sun, Topol, Eric, Fitzgerald, Kate, Reis e Sousa, Caetano, Corbett, Kizzmekia S., Bauer, Stefan   +8 more
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Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant

Frontiers in Immunology, 2022
The newly emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains more than 30 mutations on the spike protein, 15 of which are located within the receptor binding domain (RBD).
Jinkai Zang, Yannan Yin, Shiqi Xu, Weihua Qiao, Qiuyue Liu, Dimitri Lavillette, Chao Zhang, Haikun Wang, Zhong Huang   +8 more
doaj   +1 more source

Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases

RNA Biology, 2022
Messenger RNA (mRNA) vaccines have been studied for decades, but only recently, during the COVID-19 pandemic, has the technology garnered noteworthy attention.
Nusrat Zahan Rouf, Sumit Biswas, Nawseen Tarannum, Labiba Mustabina Oishee, Mutia Masuka Muna   +4 more
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OVERVIEW ON MRNA VACCINES BEYOND COVID-19

International Journal of Infectious Diseases, 2023
COVID-19 mRNA vaccines: COVID-19 pandemic has made an extraordinary impact on global vaccine technology platform developments. Never in human history have there at least 6 vaccine platforms including: inactivated, protein subunit, VLP and other 3 new ...
Kiat Ruxrungtham
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COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

The Lancet, 2021
Background BNT162b2 mRNA and ChAdOx1 nCOV-19 adenoviral vector vaccines have been rapidly rolled out in the UK from December, 2020. We aimed to determine the factors associated with vaccine coverage for both vaccines and documented the vaccine ...
V. Hall, S. Foulkes, A. Saei, N. Andrews, B. Oguti, Andre Charlett, E. Wellington, J. Stowe, N. Gillson, A. Atti, J. Islam, I. Karagiannis, K. Munro, J. Khawam, Meera Chand, C. Brown, Mary E. Ramsay, Jamie LopezBernal, Susan Hopkins, N A H T CS D C MA A H M J S J S S N R L VJ P S J K D Andrews Atti Aziz Brooks Brown Camero Carr Chand C, N. Andrews, A. Atti, H. Aziz, T. Brooks, CS Brown, D. Camero, C. Carr, M. Chand, A. Charlett, H. Crawford, M. Cole, J. Conneely, S. D’Arcangelo, J. Ellis, S. Evans, S. Foulkes, N. Gillson, R. Gopal, L. Hall, Vj Hall, P. Harrington, S. Hopkins, J. Hewson, K. Hoschler, D. Ironmonger, J. Islam, M. Kall, I. Karagiannis, O. Kay, J. Khawam, E. King, P. Kirwan, R. Kyffin, A. Lackenby, M. Lattimore, E. Linley, J. Lopez-Bernal, L. Mabey, R McGregor, S. Miah, E. Monk, K. Munro, Z. Naheed, A. Nissr, A. O’Connell, B. Oguti, H. Okafor, S. Organ, J. Osbourne, A. Otter, M. Patel, S. Platt, D. Pople, K. Potts, M. Ramsay, J. Robotham, S. Rokadiya, C. Rowe, A. Saei, G. Sebbage, A. Semper, M. Shrotri, R. Simmons, A. Soriano, P. Staves, S. Taylor, A. Taylor, A. Tengbe, S. Tonge, A. Vusirikala, S. Wallace, E. Wellington, M. Zambon, D. Corrigan, M. Sartaj, L. Cromey, S. Campbell, K. Braithwaite, L. Price, L. Haahr, S. Stewart, E. Lacey, L. Partridge, G. Stevens, Y. Ellis, H. Hodgson, C. Norman, B. Larru, S. Mcwilliam, A. Roynon, J. Northfield, S. Winchester, P. Cieciwa, A. Pai, P. Bakker, C. Loughrey, A. Watt, F. Adair, A. Hawkins, A. Grant, R. Temple-Purcell, J. Howard, N. Slawson, C. Subudhi, S. Davies, A. Bexley, R. Penn, N. Wong, G. Boyd, A. Rajgopal, A. Arenas-Pinto, R. Matthews, A. Whileman, R. Laugharne, J. Ledger, T. Barnes, C. Jones, N. Osuji, N. Chitalia, T. Bailey, S. Akhtar, G. Harrison, S. Horne, N. Walker, K. Agwuh, V. Maxwell, J. Graves, S. Williams, A. O'Kelly, P. Ridley, A. Cowley, H. Johnstone, P. Swift, J. Democratis, M. Meda, S. Brake, J. Gunn, A. Selassi, S. Hams, V. Irvine, B. Chandrasekaran, C. Forsyth, J. Radmore, C. Thomas, K. Brown, S. Roberts, P. Burns, K. Gajee, T. Lewis, T. Byrne, F. Sanderson, S. Knight, E. Macnaughton, Bjl Burton, H. Smith, R. Chaudhuri, J. Aeron-Thomas, K. Hollinshead, R. Shorten, A. Swan, C. Favager, J. Murira, S. Baillon, S. Hamer, A. Shah, J. Russell, D. Brennan, A. Davé, A. Chawla, F. Westwell, D. Adeboyeku, P. Papineni, C. Pegg, M. Williams, Sahar Ahmad, A. Horsley, C. Gabriel, K. Pagget, G. Maloney, J. Ashcroft, I. Del Rosario, R. Crosby-Nwaobi, D. Flanagan, D. Dhasmana, S. Fowler, E. Cameron, L. Prentice, C. Sinclair, V. Bateman, K. McLelland-Brooks, A. Ho, M. Murphy, A. Cochrane, A. Gibson, K. Black, K. Tempeton, S. Donaldson, L. Coke, N. Elumogo, J. Elliott, D. Padgett, A. Cross, M. Mirfenderesky, S. Joyce, I. Sinanovic, M. Howard, P. Cowling, M. Brazil, E. Hanna, A. Abdelrazik, S. Brand, Earl Sheridan, B. Wadams, A. Lloyd, J. Mouland, J. Giles, G. Pottinger, H. Coles, M. Joseph, M. Lee, S. Orr, H. Chenoweth, D. Browne, C. Auckland, R. Lear, T. Mahungu, A. Rodger, S. Warren, D. Brooking, S. Pai, R. Druyeh, E. Smith, S. Stone, S. Meisner, D. Delgado, E. Underhill, L. Keen, M. Aga, P. Domingos, S. Gormley, C. Kerrison, S. Birch, T. Desilva, L. Allsop, S. Ambalkar, M. Beekes, S. Jose, J. Tomlinson, S. Painter, C. Price, J. Pepperell, K. James, T. Trinick, L. Moore, J. Day, A. Boulos, I. Knox, E. Defever, D. McCracken, K. Gray, A. Houston, T. Planche, R. P. Pritchard Jones, Diane Wycherley, S. Bennett, J. Marrs, K. Nimako, B. Stewart, S. Bain, N. Kalakonda, S. Khanduri, A. Ashby, M. Holden, N. Mahabir, J. Harwood, B. Payne, K. Court, N. White, R. Longfellow, L. Hughes, M. Green, M. Halkes, P. Mercer, A. Roebuck, E. Wilson-Davies, L. Gallego, R. Lazarus, N. Aldridge, L. Berry, F. Game, T. Reynolds, C. Holmes, M. Wiselka, A. Higham, M. Booth, C. Duff, J. Alderton, D. Hilton, J. Powell, A. Jackson, A. Plant, N. Ahmed, T. Chin, MZ Qazzafi, A. Moody, R. Tilley, T. Donaghy, M. O'Kane, K. Shipman, R. Sierra, C. Parmar, G. Mills, D. Harvey, Ywj Huang, J. Birch, L. Robinson, S. Board, A. Broadley, C. Laven, N. Todd, D. Eyre, K. Jeffery, S. Dunachie, C. Duncan, P. Klenerman, L. Turtle, H. Baxendale, J. Heeney   +347 more
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In Gratitude for mRNA Vaccines

New England Journal of Medicine, 2021
mRNA Vaccine Research and the Lasker–DeBakey Award Although the production time (11 months) of the messenger RNA vaccines against SARS-CoV-2 infection set a record, the preclinical research undergi...
openaire   +2 more sources

mRNA Vaccine Platform: mRNA Production and Delivery

Russian Journal of Bioorganic Chemistry, 2023
Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R., Rudometov, A. P., Karpenko, L. I., Ilyichev, A. A.   +3 more
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Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques

Frontiers in Immunology, 2022
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens developed ...
Antonio Valentin, Cristina Bergamaschi, Margherita Rosati, Matthew Angel, Matthew Angel, Robert Burns, Mahesh Agarwal, Janina Gergen, Benjamin Petsch, Lidia Oostvogels, Edde Loeliger, Kara W. Chew, Steven G. Deeks, James I. Mullins, James I. Mullins, James I. Mullins, George N. Pavlakis, Barbara K. Felber   +17 more
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Recent Updates on mRNA Vaccines

Vaccines, 2022
Messenger RNA has been studied by everyone, from vaccine developers to high school biology students, since the discovery of its isolation in 1961 [...]
Emily Sydow, Abu Salim Mustafa, Asma Hanif, Javed Tunio, Shumaila Nida Muhammad Hanif   +4 more
openaire   +3 more sources