Results 51 to 60 of about 20,644 (202)

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection

BMC Infectious Diseases, 2021
Background The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly
Wenwen Jiang, Chen Wei, Dachao Mou, Weilun Zuo, Jiangli Liang, Xiao Ma, Lichan Wang, Na Gao, Qin Gu, Peng Luo, Yan Ma, Jingyan Li, Shuyuan Liu, Li Shi, Mingbo Sun   +14 more
doaj   +1 more source

The resurgence of pertussis [PDF]

Canadian Medical Association Journal, 2015
Pertussis (whooping cough) is caused by the bacterium Bordetella pertussis . In children, pertussis classically presents with paroxysms of coughing followed by a post-tussive inspiratory whooping sound.[1][1] In older individuals, its sole manifestation may be protracted cough; therefore ...
J Brad, Wiggers, Jerome A, Leis, Wayne L, Gold   +2 more
openaire   +2 more sources

Does Breastfeeding Protect Young Infants from Pertussis? Case-Control Study and Immunologic Evaluation

, 2017
Background: Pertussis infection can be severe in unvaccinated infants. A case-control study was conducted to investigate the potential role of breast-feeding in protecting young, unvaccinated infants from pertussis.
Carsetti Rita, Pandolfi Elisabetta, Villani A, Pertussis Study Group, Midulla Fabio, Carloni E, Fedele G, Fedele Giorgio, Stefanelli Paola, Tozzi Alberto Eugenio, Pandolfi E, MIDULLA, Fabio, Stefanelli P, Gesualdo F, Tozzi AE, Carsetti R, Carloni Emanuela, Gesualdo Francesco   +17 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Seroprevalence of Antibodies to Pertussis Toxin among Different Age Groups in Thailand after 37 Years of Universal Whole-Cell Pertussis Vaccination. [PDF]

PLoS ONE, 2016
Despite the high coverage of prophylactic vaccine against Bordetella pertussis infection in many countries for more than three decades, pertussis remains a common vaccine-preventable disease. Infections have been detected more commonly in countries using
Nasamon Wanlapakorn, Varisara Ngaovithunvong, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Sompong Vongpunsawad, Yong Poovorawan   +5 more
doaj   +1 more source

Infant immunization and family size

, 2004
Background To investigate whether a delay in infant immunization is associated with the number of older siblings. Methods A cohort analysis of cumulative immunization uptake in 616 children aged 1–4 years recruited for a case–control study of atopic ...
Surridge, Heidi, Surridge, H., Adamson, R., Reading, R., Adamson, Ruth, Reading, Richard   +5 more
core   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Molecular detection of Bordetella holmesii in two infants with pertussis-like syndrome: the first report from Iran

Iranian Journal of Microbiology, 2017
Background and Objectives: Bordetella holmesii is associated with a pertussis-like respiratory syndrome in healthy individuals and also a rare cause of septicaemia, endocarditis, pneumonia, and septic arthritis, mostly in immunocompromised patients ...
Masoumeh Nakhost Lotfi, Vajiheh Sadat Nikbin, Omid Nasiri, Farzad Badmasti, Fereshteh Shahcheraghi   +4 more
doaj  

How to improve pertussis vaccination in pregnancy: a European expert review

Expert Review of Vaccines
Introduction Pertussis vaccination in pregnancy is a safe and highly effective strategy to protect young infants against severe pertussis, but cases continue to occur.
Adam Finn, Nicole Guiso, Carl Heinz Wirsing von König, Federico Martinón-Torres, Arto A. Palmu, Paolo Bonanni, Pierre Bakhache, Helena C. Maltezou, Pierre Van Damme   +8 more
doaj   +1 more source