Results 41 to 50 of about 3,335 (157)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

open access: yesAdvanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu   +12 more
wiley   +1 more source

Allelic variations between vaccine strains and circulating strains in pxtP of Bordetella pertussis in Iran

open access: yesVaccine Research, 2015
Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi   +2 more
doaj  

Rediscovering Pertussis [PDF]

open access: yesFrontiers in Pediatrics, 2016
Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytosis, and death. Over the past years,
openaire   +2 more sources

Characterization of a predominant Bordetella pertussis strain isolated from Iranian patients

open access: yesVaccine Research, 2018
Introduction: Pathogen adaptation is considered as one of the important reasons for the emergence of pertussis (whooping cough). Antigenic divergence between vaccine strains and clinical isolates of Bordetella pertussis has been occurred over the years ...
VS Nikbin   +5 more
doaj  

Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Pertussis is a respiratory infection caused by the Gram-negative bacterium Bordetella pertussis. Despite high vaccination coverage this disease remains a public health concern worldwide.
Michiel M. Kroes   +9 more
doaj   +1 more source

The potential of wastewater monitoring as a novel surveillance tool for early warning of Bordetella pertussis outbreaks

open access: yesEmerging Microbes and Infections
The prolonged latency period and delayed reporting of clinical surveillance data have led to a sluggish response to Bordetella pertussis outbreaks in China.
Songzhe Fu   +9 more
doaj   +1 more source

A Small‐Scale Regional External Quality Assessment of Nucleic Acid Amplification Tests for Bordetella pertussis in China

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
An external quality assessment (EQA) was conducted to evaluate the performance of nucleic acid amplification tests (NAATs) for Bordetella pertussis across 69 laboratories in Chongqing, China. Among 345 total reports, 341 (98.8%) were concordant with expected results, while four false negatives occurred in low‐concentration samples near the analytical ...
Yuanyuan Guo   +6 more
wiley   +1 more source

Comparison of culture and real-time PCR for detection of Bordetella pertussis isolated from patients in Iran

open access: yesIranian Journal of Microbiology, 2013
Background and Objective: Due to contagiousness of pertussis, a rapid and sensitive method for diagnosis is required to initiate the treatment and interrupt its transmission. Materials and Methods: To detect B.
Vajiheh Sadat Nikbin   +4 more
doaj  

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

open access: yes
Arthritis Care &Research, EarlyView.
Catherine Deffendall   +6 more
wiley   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money   +5 more
wiley   +1 more source

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