Results 81 to 90 of about 499,378 (209)

The cGAS–STING Pathway Drives Astrocyte‐Mediated Demyelination in Multiple Sclerosis Through Clusterin Secretion

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In multiple sclerosis, astrocytes detect extracellular DNA via the cGAS–STING pathway, triggering Clusterin secretion that induces oligodendrocyte apoptosis and demyelination. Pharmacological STING inhibition with H‐151 suppresses this neurotoxic cascade, preserves myelin integrity, and ameliorates clinical disability in experimental autoimmune ...
Shengfei Hu, Xia Xiao, Xi Cheng, Yiying Huang, Tingting Cui, Shishi Shen, Chunping Cui, Li Xiao, Hanzhang Tan, Wei Qiu, Yipeng Zhao, Rui Li   +11 more
wiley   +1 more source

Pertussis Surveillance in Private Pediatric Practices, France, 2002–2006

Emerging Infectious Diseases, 2008
To the Editor: In France, pertussis epidemiology has been extensively studied since 1993. Immunization of children with a highly efficacious pertussis whole-cell (Pw) vaccine (Sanofi Pasteur MSD, Lyon, France) for 40 years (since 1966) has reduced the incidence of pertussis.
Nicole Guiso, France de La Rocque, Elisabeth Njamkepo, Aurelie Lécuyer, Corinne Levy, Olivier Romain, Franck Thollot, Véronique Abitbol, Benoit Soubeyrand, Robert Cohen, Thérapeutique Infantile du Val de Marne   +10 more
openaire   +3 more sources

Understanding the High Incidence of Pertussis in Norway: The Role of Test Activity

Acta Paediatrica, EarlyView.
Margrethe Greve‐Isdahl, Elina Seppälä   +1 more
wiley   +1 more source

A Small‐Scale Regional External Quality Assessment of Nucleic Acid Amplification Tests for Bordetella pertussis in China

Journal of Clinical Laboratory Analysis, Volume 40, Issue 16, August 2026.
An external quality assessment (EQA) was conducted to evaluate the performance of nucleic acid amplification tests (NAATs) for Bordetella pertussis across 69 laboratories in Chongqing, China. Among 345 total reports, 341 (98.8%) were concordant with expected results, while four false negatives occurred in low‐concentration samples near the analytical ...
Yuanyuan Guo, Junjiang Zhou, Zhijie Li, Jiangming Xiao, Tian Li, Changchun Niu, Yang Luo   +6 more
wiley   +1 more source

Epidemiology of Pertussis After the COVID-19 Pandemic: Analysis of the Factors Involved in the Resurgence of the Disease in High-, Middle-, and Low-Income Countries

Vaccines
Pertussis is a highly contagious bacterial disease of the respiratory tract that can be prevented by vaccination. Before the COVID-19 pandemic, the vaccine coverage rate for the third dose of a DPT-containing vaccine was 86%, with large disparities among
Lucia F. Bricks, Juan C. Vargas-Zambrano, Denis Macina   +2 more
doaj   +1 more source

MODERNIZATION OF GENEOTIPING OF STRAINS B. PERTUSSIS

Детские инфекции (Москва), 2015
The new rapid molecular genotyping method was developed for studying the structure of ptxP promoter of pertussis toxin. Method is based on PCR-RFLP analysis, which allows studying the specific restriction profiles of the B.
G. A. Ivashinnikova, O. U. Borisova, A. V. Aleshkin, A. S. Pimenova, V. A. Aleshkin   +4 more
doaj   +1 more source

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study

PM&R, Volume 18, Issue 8, Page 874-884, August 2026.
Abstract Background Spinal cerebrospinal fluid (CSF) leaks, a rare but debilitating condition, have been described following spinal manipulative therapy (SMT) in case reports. However, the nature of the potential association between SMT and CSF leak is uncertain, and symptoms such as neck pain or headache may reflect preexisting leaks rather than ...
Robert J. Trager, Collin M. Labak, Anthony N. Baumann, Tyler H. Snodgrass, Zachary A. Cupler   +4 more
wiley   +1 more source

IS481-based pertussis positivity transition from preschool to school-aged children and the ptxP3 predominance in high-load subset: a digital platform surveillance study in China

Emerging Microbes and Infections
China experienced a massive pertussis resurgence in 2024. We aimed to characterize the epidemiological trends, clinical symptoms, and molecular evolution of Bordetella pertussis using a large-scale, home-based surveillance platform in four Chinese ...
Chunyan Xiang, Zichen Lei, Tingting You, Ziyi Chu, Dong Liu, Jinghan Huang, You Li, Binghuai Lu, Bin Cao, Yeming Wang   +9 more
doaj   +1 more source

Navigating the Future of Respiratory Infections: Key Insights From International Congress in Singapore, 17–20 September 2025

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background The 8th International Society for Respiratory Viruses (ISRV) Antiviral Group Conference, held jointly with the 3rd International Meeting on Respiratory Pathogens in Singapore (17–20 September 2025), examined evolving approaches to prevention and management of respiratory infections.
Narmadha Morvil, Wilson Guo Wei Goh, Charlotte Zheng, Stephanie Sutjipto, Dorothy Hui Lin Ng, Maria Zambon   +5 more
wiley   +1 more source

EPIDEMIOLOGICAL CHARACTERISTICS OF PERTUSSIS IN PCR TESTED PATIENTS WITH SUSPECTED INFECTION [PDF]

Journal of IMAB
Purpose: To analyze epidemiological and clinical data of individuals tested for pertussis within the framework of routine disease surveillance Material and Methods: We conducted a retrospective analysis of epidemiological and clinical characteristics in
Milena Karcheva, Cvetan Popov, Polya Marinovska, Georgi Golemanov, Nelly Doseva, Maria Sredkova   +5 more
doaj   +1 more source