Results 61 to 70 of about 11,221 (162)

Pertussis Surveillance—United States, 1989-1991

JAMA: The Journal of the American Medical Association, 1993
The licensure of whole-cell pertussis vaccine combined with diphtheria and tetanus toxoids as DTP in the 1940s--and its widespread use in infants and children--led to a dramatic decline in the incidence of reported pertussis. In the prevaccine era, the average annual incidence and mortality for reported pertussis were 150 cases and six deaths per 100 ...
S F, Davis, P M, Strebel, S L, Cochi, E R, Zell, S C, Hadler   +4 more
openaire   +3 more sources

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

Acta Paediatrica, EarlyView.
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1673-1685, August 2026.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Safety Surveillance of Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) Vaccines [PDF]

Pediatrics, 2018
OBJECTIVE:To assess the safety of currently licensed diphtheria-tetanus-acellular pertussis (DTaP) vaccines in the United States by using data from the Vaccine Adverse Event Reporting System (VAERS), a spontaneous reporting surveillance system.METHODS:We searched VAERS for US reports of DTaP vaccinations occurring from January 1, 1991, through December
Pedro L, Moro, Silvia, Perez-Vilar, Paige, Lewis, Marthe, Bryant-Genevier, Hajime, Kamiya, Maria, Cano   +5 more
openaire   +2 more sources

The cGAS–STING Pathway Drives Astrocyte‐Mediated Demyelination in Multiple Sclerosis Through Clusterin Secretion

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In multiple sclerosis, astrocytes detect extracellular DNA via the cGAS–STING pathway, triggering Clusterin secretion that induces oligodendrocyte apoptosis and demyelination. Pharmacological STING inhibition with H‐151 suppresses this neurotoxic cascade, preserves myelin integrity, and ameliorates clinical disability in experimental autoimmune ...
Shengfei Hu, Xia Xiao, Xi Cheng, Yiying Huang, Tingting Cui, Shishi Shen, Chunping Cui, Li Xiao, Hanzhang Tan, Wei Qiu, Yipeng Zhao, Rui Li   +11 more
wiley   +1 more source

Pertussis surveillance in French hospitals: results from a 10 year period [PDF]

Eurosurveillance, 2007
We present 10 years of results from a paediatrician hospital network surveillance in France, set up in 1996 to monitor the trend of pertussis (whooping cough) in children and the impact of the vaccination strategies. Microbiologists from 43 hospitals that participate in the network on a voluntary basis notify pertussis diagnosis, and paediatricians ...
I Bonmarin, D Lévy-Bruhl, S Baron, N Guiso, E Njamkepo, V Caro, Collective Renacoq   +6 more
openaire   +2 more sources

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study

PM&R, Volume 18, Issue 8, Page 874-884, August 2026.
Abstract Background Spinal cerebrospinal fluid (CSF) leaks, a rare but debilitating condition, have been described following spinal manipulative therapy (SMT) in case reports. However, the nature of the potential association between SMT and CSF leak is uncertain, and symptoms such as neck pain or headache may reflect preexisting leaks rather than ...
Robert J. Trager, Collin M. Labak, Anthony N. Baumann, Tyler H. Snodgrass, Zachary A. Cupler   +4 more
wiley   +1 more source

Leveraging large language models on free-text symptoms from participatory surveillance enhances pertussis forecasting in the United States

BMC Infectious Diseases
Background Declines in childhood vaccination in the U.S. have contributed to a resurgence of vaccine-preventable diseases, including a notable increase in pertussis cases. Traditional pertussis surveillance is limited by underdiagnosis and underreporting.
Luigi De Angelis, Samuele Tarallo, Caterina Rizzo, Autumn Gertz, Francesco Baglivo, John S. Brownstein, Benjamin Rader   +6 more
doaj   +1 more source

Emergence of Bordetella holmesii–Associated Pertussis-Like Illness, Northern India, 2019–2023

Emerging Infectious Diseases
We investigated Bordetella holmesii and Bordetella pertussis in 935 suspected pertussis cases in northern India (2019–2023) using PCR and serology. B. holmesii showed increased prevalence in pertussis cases, particularly in older children, highlighting ...
Nishant Shekhar, Deepa Sharma, Surajit Chakraborty, Rajesh Kumar, Rajneesh Singh Rawat, Nirmal Kaundal, Pawan Kumar, Tigran Avagyan, Deeksha Chauhan, Neha Jain, Megha Sharma, Arun Kumar, Vikas Gautam   +12 more
doaj   +1 more source