Results 1 to 10 of about 277,369 (126)

Influence of Age on Health-Related Quality of Life of Women Diagnosed with Breast Cancer

open access: yesRevista Brasileira de Cancerologia, 2023
Introduction: Women with breast cancer may have differences in health-related quality of life (HRQoL) at diagnosis by age. Objective: To analyze the influence of age on the HRQoL of women diagnosed with breast cancer.
Larissa Nascimento dos Santos   +4 more
doaj   +1 more source

Assessment of small in-frame indels and C-terminal nonsense variants of BRCA1 using a validated functional assay

open access: yesScientific Reports, 2022
BRCA1 (Breast Cancer 1, early onset) is linked to breast and ovarian cancer predisposition. Still, the risks conferred by a significant portion of BRCA1 variants identified in the population remains unknown.
Thales C. Nepomuceno   +9 more
doaj   +1 more source

IMPLANTAÇÃO DE DIRETRIZ CORPORATIVA PARA A PADRONIZAÇÃO DOS CUIDADOS FARMACÊUTICOS NA TERAPIA CAR-T CELL EM TRÊS HOSPITAIS DE UMA REDE NACIONAL DE SAÚDE INTEGRADA

open access: yesHematology, Transfusion and Cell Therapy, 2023
Introdução e objetivos: A terapia CAR-T cell é uma inovadora modalidade terapêutica que revolucionou o tratamento das doenças oncohematológicas. Atualmente, dispomos de alguns medicamentos com CAR-T cell aprovados no Brasil e para indicações restritas. O
RBR Tolentino   +4 more
doaj   +1 more source

The “home-based exercise for breast and prostate cancer patients during treatment—a feasibility trial” (BENEFIT CA trial): rationale and methodological protocol

open access: yesPilot and Feasibility Studies, 2023
Background Physical activity has been shown to benefit patients undergoing adjuvant cancer therapy. Although exercise interventions may be applied in several settings, most trials have focused on specialized facilities for their interventions.
Larissa Xavier Neves da Silva   +7 more
doaj   +1 more source

Impacto de Marcadores Inflamatórios no Prognóstico de Pacientes Oncológicos Internados no Instituto Nacional de Câncer com SARS-CoV-2 na Primeira Onda da Pandemia no Brasil

open access: yesRevista Brasileira de Cancerologia, 2023
Introdução: O intenso processo inflamatório desencadeado pela covid-19 tem sido apontado por diversos autores. Objetivo: Avaliar o impacto de marcadores inflamatórios no prognóstico de pacientes com tumores sólidos internados com SARS-CoV-2/covid-19 na ...
Danielly Aguiar Martins da Silva   +8 more
doaj   +1 more source

Avaliação da legislação e normas vigentes para bioensaios aplicados em pesquisa clínica: um estudo de caso para comprovação de imunogenicidade de vacinas

open access: yesVigilância Sanitária em Debate, 2016
As vacinas são produtos imunobiológicos reconhecidamente seguros, eficazes e fundamentais no controle e/ou erradicação de doenças imunopreveníveis, sendo submetidas a testes analíticos e bioensaios para comprovação da qualidade e eficácia terapêutica. Neste trabalho foi avaliada a aplicabilidade da Resolução da Diretoria Colegiada da Agência Nacional ...
Ester Ribeiro de Figueiredo   +3 more
openaire   +5 more sources

Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

open access: yesMalaria Journal, 2021
Background The relapsing nature of Plasmodium vivax infection is a major barrier to its control and elimination. Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P.
Anielle de Pina-Costa   +12 more
doaj   +1 more source

Hiperglicemia e doença cardiovascular podem coexistir [PDF]

open access: yes, 2008
Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MedicinaUNIFESP-EPM Centro de Pesquisa Clínica em DiabetesUNIFESP, EPM, Depto.
Alvarenga, Marcelo Alves   +1 more
core   +2 more sources

Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer. [PDF]

open access: yes, 2014
IntroductionThe purpose of this study was to retrospectively explore the relationship between human epidermal growth factor receptor 2 (HER2) messenger RNA (mRNA) expression and efficacy in patients receiving trastuzumab plus docetaxel (HT) or ...
Amler, Lukas C   +6 more
core   +3 more sources

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study

open access: yesNutrition Journal, 2017
Background Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies.
Paula Simplício da Silva   +10 more
doaj   +1 more source

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