Results 41 to 50 of about 416,778 (248)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Characterization of PET image using global and local entropy

Brazilian Journal of Radiation Sciences, 2015
In the clinical practice PET imaging provides semi-quantitative information about metabolic activities in human body, using the Standardized Uptake Value (SUV).
Igor Fagner Vieira
doaj   +1 more source

(Radio)Theranostic Patient Management in Oncology Exemplified by Neuroendocrine Neoplasms, Prostate Cancer, and Breast Cancer

Pharmaceuticals, 2020
The role of nuclear medicine in the management of oncological patients has expanded during last two decades. The number of radiopharmaceuticals contributing to the realization of theranostics/radiotheranostics in the context of personalized medicine is ...
Irina Velikyan
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Rabbit model of Staphylococcus aureus implant-associated spinal infection

Disease Models & Mechanisms, 2020
Post-surgical implant-associated spinal infection is a devastating complication commonly caused by Staphylococcus aureus. Biofilm formation is thought to reduce penetration of antibiotics and immune cells, contributing to chronic and difficult-to-treat ...
Oren Gordon, Robert J. Miller, John M. Thompson, Alvaro A. Ordonez, Mariah H. Klunk, Dustin A. Dikeman, Daniel P. Joyce, Camilo A. Ruiz-Bedoya, Lloyd S. Miller, Sanjay K. Jain   +9 more
doaj   +1 more source

Pet Rabbits

Veterinary Clinics of North America: Small Animal Practice, 1994
Pet rabbits are becoming more common, and rabbit owners are demanding quality veterinary care. This article provides a broad overview of pet rabbit medicine, which is a relatively new field compared to laboratory and farm rabbit medicine. The most common differential diagnoses for presenting complaints are summarized in table form.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Respiratory motion correction of PET using MR-constrained PET-PET registration [PDF]

BioMedical Engineering OnLine, 2015
Respiratory motion in positron emission tomography (PET) is an unavoidable source of error in the measurement of tracer uptake, lesion position and lesion size. The introduction of PET-MR dual modality scanners opens a new avenue for addressing this issue. Motion models offer a way to estimate motion using a reduced number of parameters.
Balfour, Daniel Robert Malcolm, Marsden, Paul Kenneth, Polycarpou, Irene, Kolbitsch, Christoph Philipp, King, Andrew Peter   +4 more
openaire   +5 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Hybrid Compton-PET imaging for Ion-Range Monitoring in Hadron Therapy [PDF]

EPJ Web of Conferences
Hadron therapy is a rapidly growing cancer treatment, offering high precision in targeting tumors while sparing healthy tissue. However, its full potential is limited by uncertainties in the range of therapeutic ions, largely due to current reliance on X-
Balibrea-Correa J., Babiano-Suarez V., Lerendegui-Marco J., Torres-Sánchez P., Ladarescu I., Pallàs M., Brusasco B., Wulff J., Bäumer C., Rossomme Severine, Warnier Alexis, Tarifeño-Saldivia A., Domingo-Pardo C.   +12 more
doaj   +1 more source