Results 141 to 150 of about 3,305,923 (243)

Ultranarrow bright single-photon emitters in diamond with strong broadband phonon decoupling. [PDF]

Nat Commun
Sahoo S, Udvarhelyi P, Li J, Kim D, Agafonov V, Davydov VA, Lawrie B, Narang P, Bogdanov SI.   +8 more
europepmc   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Readout of a solid state spin ensemble at the projection noise limit. [PDF]

Nat Commun
Maier R, Ho CI, Denisenko A, Davydova M, Knittel P, Wrachtrup J, Vorobyov V.   +6 more
europepmc   +1 more source

A phase IIa study of the anti‐PD‐L1 antibody avelumab in relapsed/refractory PTCL: The AVAIL‐T trial

British Journal of Haematology, EarlyView.
The AVAIL‐T study, the first evaluation of programmed death ligand 1 (PD‐L1) blockade in relapsed/refractory peripheral T‐cell lymphomas (PTCL), demonstrated limited single agent activity with durable responses seen in a minority. Circulating tumour DNA revealed distinct mutational dynamics and mass cytometry identified perturbed T‐cell subsets ...
Matthew J. Ahearne, Matthew A. Timmins, Charlotte Gaskell, Aimee Jackson, Clare Morland, Sonia Fox, Louise Hopkins, Nadia Nawaz, Susann Lehmann, Marc Wadsley, Caroline Cowley, Jacqueline Shaw, Naeem Khan, Nagesh Kalakonda, Christopher Trethewey, Ram Malladi, Paul Fields, Dima El Sharkawi, Michael Quinn, Nimish Shah, Andrew Davies, Kim Linton, Pam McKay, Rod Johnson, Simon D. Wagner, David Lewis, Graham P. Collins, Christopher P. Fox, Kate Cwynarski   +28 more
wiley   +1 more source

Impact of Environmental Conditions During IVF Laboratory Handling on Sperm Quality. [PDF]

Int J Mol Sci
Czétány P, Balló A, Márk L, Farkas N, Szántó Á, Máté G.   +5 more
europepmc   +1 more source

D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose D‐amino acid oxidase (DAO) has been developed as a chemogenetic tool, to precisely manipulate redox levels in tissues and cells by generating H2O2 in the presence of D‐amino acids. The enzyme's significant oxygen consumption during H2O2 production may influence cellular oxygen levels.
Wiebke Maurer, Anke Zieseniss, Vamsi Priya Vikram, Yamin Chen, Laura Bauer, Annette Hillemann, Peter Rehling, Maithily S. Nanadikar, Diane de Zélicourt, Vartan Kurtcuoglu, Dörthe M. Katschinski   +10 more
wiley   +1 more source

An achromatic neutron lens. [PDF]

Nat Commun
Dhanalakshmi Veeraraj MR, Qu D, Chen HY, Strebel S, Qi P, Fedrigo A, Helfen L, Tengattini A, Busi M, Wang H, Tranchida P, Kaestner A, David C, Strobl M, Vila-Comamala J.   +14 more
europepmc   +1 more source

Collusion through debt and managers

Canadian Journal of Economics/Revue canadienne d'économique, EarlyView.
Abstract We investigate the anticompetitive effects of debt financing and managerial incentives in the presence of managers incurring personal bankruptcy costs. We characterize the strategic value for firms' shareholders of resorting to debt and managerial incentives as complementary devices to sustain collusion among firms, when managerial bankruptcy ...
Raffaele Fiocco, Salvatore Piccolo, Giancarlo Spagnolo   +2 more
wiley   +1 more source

Strain-Induced Electrical Conductivity in Diamond Nanowires. [PDF]

Nano Lett
Pieshkov TS, Barri N, Zhou Y, Shin B, Islam MA, Kumral B, Serles P, Steinbach D, Murukeshan J, Biswas A, Li C, Lou J, Han Y, Filleter T, Vajtai R, Avila R, Ajayan PM.   +16 more
europepmc   +1 more source

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy (NIR‐PIT)

Cancer Science, EarlyView.
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi   +9 more
wiley   +1 more source