Results 181 to 190 of about 4,712 (265)

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

open access: yesAngewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern   +9 more
wiley   +2 more sources

Covalent Immobilisation of PVA‐MA Hydrogels on Plasma‐Activated Coatings: Achieving Superior Adhesion by Reagent‐Free Formation of a Nanoscale Primer Layer

open access: yesAdvanced NanoBiomed Research, EarlyView.
Robust attachment of hydrogels to solid substrates is critical to success in cell culture where hydrostatic and contractile forces can contribute to delamination of weakly adhered gels. This novel approach forms a nanometer‐scale, reagent‐free hydrogel primer layer to provide improved resistance to delamination of subsequent bulk hydrogel layers in a ...
Sophia C. Franklin   +7 more
wiley   +1 more source

Novel Interdigitated Electrode Conductometric Sensor for Rapid, Sensitive, and Selective Detection of cTnI Biomarkers in Saliva

open access: yesAdvanced NanoBiomed Research, EarlyView.
A miniaturized high resistivity silicon‐based interdigitated conductometric sensor detects cTnI at sub‐femtomolar levels with high selectivity. The device enables noninvasive testing using artificial and pooled human saliva in real‐time electrical readings. This portable biosensor offers a promising futuristic medical device providing new opportunities
Preethi Chidambaram   +8 more
wiley   +1 more source

Modeling antibiotic resistance in the microbiota using multi-level Petri Nets. [PDF]

open access: yesBMC Syst Biol, 2018
Bardini R   +3 more
europepmc   +1 more source

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