Results 221 to 230 of about 936,090 (350)

Three‐Component Synthesis of γ‐Amino Esters with α‐Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
γ‐Amino acid derivatives with an α‐quaternary center are prevalent in medicinally important compounds. A dual N‐heterocyclic carbene/photocatalytic pathway is developed for the three‐component synthesis of α, α ‐disubstituted γ‐amino esters. This methodology allows for the rapid synthesis of diverse libraries of γ‐amino esters in good yields.
Adam X. Wayment, Karl A. Scheidt
wiley   +1 more source

Gold‐Catalyzed Synthesis of Fluorenones via Intramolecular C–H Arylation

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Starting from 2‐diazobenzophenones, a straightforward synthesis of valuable fluorenones via a gold‐catalyzed one‐pot oxidation, C–H activation, and cyclization is described. The addition of ascorbic acid, the correct selection of the counteranion of the 2‐diazobenzophenones, and the use of terpyridine as an auxiliary ligand are crucial for the reaction
Osvaldo Felipe López‐Saladino   +5 more
wiley   +1 more source

Photocatalytic Polyene Cyclization to Cyclopentyl Thioethers with Consecutive Quaternary Centers in Fluorinated Alcohols

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
A photocatalytic strategy enables efficient cyclization of polyenes to cyclopentyl thioethers with consecutive all‐carbon quaternary centers. Using 2,4,6‐triphenylpyrylium tetrafluoroborate in 1,1,1,3,3,3‐hexafluoroisopropanol, the method proceeds via a thiyl radical mechanism, offering high yields and good diastereoselectivities.
Nicolás Rascón   +2 more
wiley   +1 more source

Harnessing Vinylogy with Radicals: Photoinduced γ‐Benzylation Reactions of 2‐Silyloxyfurans

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Two radical‐mediated benzylations of 2‐silyloxyfurans, promoted by visible light and suitable photoredox catalysts have been disclosed. A broad scope of γ‐benzyl butenolides was obtained in one step, some of which were used as strategic precursors to bio‐valuable chiral butanolides.
Enrico Marcantonio   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy