Results 281 to 290 of about 2,751,852 (326)

Dearomative Higher‐Order Cycloaddition for the Construction of Dihydropyrimidin‐4(1H)‐One Scaffold Employing N‐Heterocyclic Carbene Catalysis

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
The study presents dearomative higher‐order cycloaddition as an effective strategy for constructing the biologically important dihydropyrimidin‐4(1H)‐one core. The method employs indole‐7‐carbaldehydes as precursors of higherenes, which, under N‐heterocyclic carbene (NHC) catalysis, generate NHC‐bound aza‐o‐quinodimethanes.
Adam Cieśliński   +3 more
wiley   +1 more source

Potential Advances in the Design of Sealants for Geologic Conformance Control toward CO<sub>2</sub> Storage Security. [PDF]

open access: yesACS Omega
Afolabi F   +7 more
europepmc   +1 more source

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg   +5 more
wiley   +1 more source

Domino Synthesis of Functionalized Cyclic Acetals From Organic Carbonates

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Cyclic carbonates equipped with acrylic functional groups are shown to undergo a domino process in the presence of a suitable alkoxide to deliver novel types of decorated cyclic acetals. The developed protocol combines practical conditions and a wide scope and features a new reactivity modus for these carbon dioxide‐derived heterocyclic precursors.
Natalia Kulbacka   +5 more
wiley   +1 more source

Polylactic Acid (PLA), Polycaprolactone (PCL), and Chitosan: the Biodegradable Transition in Medical Waste Management

open access: yesAdvanced Sustainable Systems, EarlyView.
The shift to biodegradable materials in healthcare promises reduced plastic pollution, but their production, adoption, and long‐term impacts remain complex. Integrating lifecycle insights with global policy coordination is essential for meaningful environmental gains. Abstract The COVID‐19 pandemic sharply increased medical waste, intensifying concerns
By Haoxuan Yu   +2 more
wiley   +1 more source

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