Results 171 to 180 of about 42,662 (265)
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia +13 more
wiley +1 more source
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang +4 more
wiley +1 more source
Under the weakly alkaline condition, at pH 12, the *OH adsorption–mediated mechanism of direct aldehyde oxidation is demonstrated to complete HMF oxidation to FDCA, obtaining >95% selectivity and yield. In OH−‐deficient media, high FDCA selectivity is achieved on the CuO/NiOOH interface, a synergistic active site, where Cu enhances *OH utilization, and
Eunchong Lee +8 more
wiley +1 more source
Effects of shift and night work in the offshore petroleum industry: a systematic review. [PDF]
Fossum IN +3 more
europepmc +1 more source

