Results 81 to 90 of about 167 (166)

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles

Advanced Science, EarlyView.
Pd(II)/Cu(I) co‐catalyzed dual Csp2─Csp3 bonds construction from unactivated alkenes and arylsulfonyl chlorides to access benzo‐fused heterocycles with high efficiency and chemoselectivity. Abstract Transition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material ...
Jiahui Huang, Yuantao You, Yijian Ma, Xingying He, Yixiao Li, Arunachalam Kesavan, Chengzhi Jin, Chengshuo Shen, Min Zhang, Kedong Yuan   +9 more
wiley   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Radical‐Polar Crossover Bicyclization Enables a Modular Synthesis of Saturated Bicyclic Amines

Advanced Science, EarlyView.
Herein, we report the successful realization of a radical‐polar crossover bicyclization reaction from easily available cyclopropylamines and substituted alkenes through photoredox catalysis. This approach introduces an innovative methodology for the de novo synthesis of a diverse collection of 4/5‐, 5/5‐, 6/5‐,7/5‐ and 5/6‐fused saturated bicyclic ...
Dewei Feng, Xiao Geng, Lingling Zuo, Zhifang Li, Lei Wang   +4 more
wiley   +1 more source

Sinter‐ and Water‐Resistant Pt Enabled by High Entropy of Porous Oxide Nanofibers

Advanced Science, EarlyView.
The high‐entropy effect thermodynamically favors a unique distribution of multiple constituent elements within the crystalline lattice with low Gibbs free energy. This special configuration endows the material with exceptional stability, depressing the growth of Pt species at elevated temperatures.
Yunpeng Wang, Mingyu Tang, Zhuxin Lyu, Wanlin Fu, Han Yan, Shiming Zhou, Yueming Sun, Yunqian Dai   +7 more
wiley   +1 more source

In Situ Converting Conformal Sacrificial Layer Into Robust Interphase Stabilizes Fluorinated Polyanionic Cathodes for Aqueous Sodium‐Ion Storage

Advanced Science, EarlyView.
A unique interfacial conversion concept is proposed to establish robust cathode electrolyte interphase for stabilizing fluorinated polyanionic cathodes in aqueous electrolytes. In a typical case, the conformal Al2O3 sacrificial layer is predeposited on high‐voltage sodium vanadium oxy‐fluorophosphates cathode, which can progressively react with trace ...
Peng Gong, Shibo Chai, Xingjie Li, Yibo Dong, Shengjun Zhai, Xihao Chen, Ning Wang, Yuanyuan Li, Jinping Liu   +8 more
wiley   +1 more source