Results 51 to 60 of about 1,386 (148)

A novel role of peroxin PEX6: suppression of aging defects in mitochondria

Aging Cell, 2007
SummaryYeast cells become older with each division, but their daughters are born young. Mutational analysis shows that maintenance of this age asymmetry requires segregation of a complement of active mitochondria to daughters and that this process breaks down in older mother cells.
Jae-Gu, Seo, Chi-Yung, Lai, Michael V, Miceli, S Michal, Jazwinski   +3 more
openaire   +2 more sources

Identification of intragenic mutations in the Hansenula polymorpha PEX6 gene that affect peroxisome biogenesis and methylotrophic growth [PDF]

, 2003
Two interacting AAA ATPases, Pex1p and Pex6p, are indispensable for peroxisome biogenesis in different organisms. Mutations affecting corresponding genes are the most common cause of the peroxisome biogenesis disorders in humans. By UV mutagenesis of the
Veenhuis, M, Stasyk, Oleh V., Stasyk, OV, Pochapinsky, Olexiy D., Sibirny, AA, Nazarko, Volodymyr Y., Nazarko, TY, Nazarko, VY, Pochapinsky, OD, Nazarko, Taras Y.   +9 more
core   +2 more sources

AWP1/ZFAND6 Functions in Pex5 Export by Interacting with Cys‐Monoubiquitinated Pex5 and Pex6 AAA ATPase [PDF]

Traffic, 2011
During biogenesis of the peroxisome, a subcellular organelle, the peroxisomal‐targeting signal 1 (PTS1) receptor Pex5 functions as a shuttling receptor for PTS1‐containing peroxisomal matrix proteins. However, the precise mechanism of receptor shuttling between peroxisomes and cytosol remains elusive despite the identification of numerous peroxins ...
Non, Miyata, Kanji, Okumoto, Satoru, Mukai, Masafumi, Noguchi, Yukio, Fujiki   +4 more
openaire   +2 more sources

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Isolation and characterization of cold sensitive pex6 mutant of the methylotrophic yeast Hansenula polymorpha [PDF]

Biopolymers and Cell, 2002
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Nazarko, V. Y., Pochapinsky, O. D., Nazarko, T. Y., Stasyk, O. V., Sibirny, A. A.   +4 more
openaire   +2 more sources

An Exome-wide Association Study for Type 2 Diabetes–Attributed End-Stage Kidney Disease in African Americans

Kidney International Reports, 2018
Introduction: Compared with European Americans, African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD). Genome-wide association studies (GWAS) have identified >70 genetic variants associated with kidney function and ...
Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Pamela J. Hicks, Jianzhao Xu, Nicholette D. Palmer, James G. Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C.Y. Ng   +9 more
doaj   +1 more source

At the Edge of Survival: Exploring the Frontiers of Tardigrade Extreme Stress Tolerance

Molecular Ecology, Volume 35, Issue 14, July 2026.
ABSTRACT Tardigrades possess extraordinary resilience to extreme environmental conditions, including near‐complete desiccation, severe levels of radiation, the vacuum of space and extreme sub‐zero temperatures. Despite significant interest in their survival strategies, the molecular mechanisms underlying their survival during extreme stresses have ...
Maria Kamilari, Frida Løkkegaard Pust, Andrea Marcantognini, Ask Møbjerg, Ricardo Cardoso Neves, Morten Schiøtt, Nadja Møbjerg   +6 more
wiley   +1 more source

Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
Peroxisomes are emerging as key regulators of lipid metabolism in leukemia. Enhanced metabolism of very‐long‐chain fatty acids (VLCFAs) supports leukemia cell survival, redox homeostasis, and therapeutic resistance. Pharmacologic disruption of peroxisomal fatty acid oxidation causes VLCFA accumulation, oxidative stress, and mitochondrial dysfunction ...
Ekaterina N. Parfenova, Paul A. Spagnuolo   +1 more
wiley   +1 more source