Results 191 to 200 of about 157,808 (244)

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Local modifications in tissular conditions before PFA increases acute lesion size. [PDF]

Heart Rhythm O2
Amorós-Figueras G, Casabella-Ramón S, Moreno-Weidmann Z, Castellví Q, Ivorra A, García-Sánchez T, Guerra JM.   +6 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Pulsed field ablation: focused on atrial fibrillation ablation. [PDF]

Korean J Intern Med
Kim HJ, Lee CH.
europepmc   +1 more source

Real-Time Prediction of Irreversible Lesion Size During Pulsed Field Ablation: Prospective Validation of a Novel Ablation Index Based on Contact Force and Number of Applications in a Swine Beating Heart Model. [PDF]

Circ Arrhythm Electrophysiol
Nakagawa H, Farshchi-Heydari S, Sugawara M, Ikeda A, Maffre J, Sharma T, Lam P, Govari A, Beeckler CT, Altmann A, Jackman WM, Franz MR, Spangler T, Hussein AA, Nakhla S, Santangeli P, Saliba WI, Wazni OM.   +17 more
europepmc   +1 more source

Catheter Ablation for Persistent Atrial Fibrillation: Rationale, Evidence, and Contemporary Strategies Beyond Pulmonary Veins. [PDF]

J Clin Med
Ruscio E, Marsilia M, Bencardino G, Narducci ML, Perna F, Comerci G, Pinnacchio G, Burzotta F, Scacciavillani R, Pelargonio G.   +9 more
europepmc   +1 more source

Novel Impedance-Guided Contact Mapping Technique for the Circular Multielectrode Pulsed-Field Ablation Catheter. [PDF]

Clin Case Rep
Yamashita K, Kikuchi Y, Yoshiyama K, Kumazawa D, Mizuno Y, Onodera K.   +5 more
europepmc   +1 more source