Results 81 to 90 of about 9,581 (268)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Beyond the Edge: Charge‐Transfer Excitons in Organic Donor‐Acceptor Cocrystals

Advanced Functional Materials, EarlyView.
Complex excitonic landscapes in acene–perfluoroacene cocrystals are unveiled by polarization‐resolved optical spectroscopy and many‐body theory. This systematic study of a prototypical model system for weakly interacting donor–acceptor compounds challenges common views of charge‐transfer excitons, providing a refined conceptual framework for ...
Sebastian Anhäuser, Ana M. Valencia, Sergei I. Ivlev, Marc Zeplichal, Andreas Terfort, Caterina Cocchi, Gregor Witte   +6 more
wiley   +1 more source

Microfluidic Platform for Multiparametric Profiling of Fibrin Permeability, Fibrinolysis, and Cell Invasion

Advanced Functional Materials, EarlyView.
This paper introduces a single‐channel H‐junction microfluidic assay that profiles fibrin's evolving function in repair and thrombosis by measuring, in one ∼3 µL gel, permeability, fibrinolysis kinetics, fibroblast invasion, and clot extension in real time.
Halston Deal, Elizabeth M. Byrnes, Sanika Pandit, Halle J. Cantor, Muskan Aslam, Stacy Ban, Megan Palmisano, Rosemary Bayless, Ashley C. Brown, Michael Daniele   +9 more
wiley   +1 more source

Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations

Environmental Health
Background Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries and consumer products due to their water-repellent properties.
Ida Karoline Bach Jensen, Esben Budtz-Jørgensen, Christian Lindh, Caroline Borup Roland, Signe de Place Knudsen, Jane M. Bendix, Stig Molsted, Tine D. Clausen, Bente Stallknecht, Ole H. Mortensen, Ellen Løkkegaard, Lisbeth E. Knudsen   +11 more
doaj   +1 more source

Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances

Ecotoxicology and Environmental Safety
Per- and poly-fluoroalkyl substances (PFAS) are highly persistent chemicals commonly found in surface protectants, and class B aqueous film forming foams (AFFF), and many other consumer and industrial products. As a result of their widespread application
Kenneth N. Kikanme, Adcharee Karnjanapiboonwong, Rameshkumar Angappan, Nicole M. Dennis, Farzana Hossain, Jamie G. Suski, Christopher J. Salice, Todd A. Anderson   +7 more
doaj   +1 more source

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Perfluoroalkyl substances in the environment and biota from the coasts of the South China Sea: profiles, sources, and potential risks

Frontiers in Environmental Science
Perfluoroalkyl substances (PFAS) are an emerging class of contaminants that have been produced since the 1950s. The first report on PFAS to raise global concerns was published in 2001. Since then, many countries have implemented policies to control PFAS.
Jiaer Zhang, Jiaer Zhang, Yuxin Xie, Yuxin Xie, Jingru Zhang, Mai Ye, Jieyi Diao, Jieyi Diao, Jianwen Wang, Jianwen Wang, Qiongping Sun, Qiongping Sun, Tieyu Wang, Tieyu Wang   +13 more
doaj   +1 more source

Biocompatible but Antibacterial Mechanism of Graphene Oxide for Sustainable Antibiotics

Advanced Functional Materials, EarlyView.
Graphene oxide (GO) exhibits selective antibacterial activity through specific interactions between its oxygen functional groups and bacterial membrane phospholipid POPG, causing membrane destabilization while maintaining biocompatibility. Model membrane studies and infected wound models in mice and pigs demonstrate effective bacterial suppression and ...
Sujin Cha, Ju Yeon Chung, Seungju Yang, Seung Cheol Lee, Chan Woo Lee, Colin Wing‐Lok Cheng, Jun Beom Kim, Nam Jun Kim, Ayoung Park, Heewon Choi, Junpyo Sinn, Ralph Weissleder, Nicholas A. Kotov, Myungeun Seo, Hyun Jung Chung, Sang Ouk Kim   +15 more
wiley   +1 more source

Perfluoroalkyl Substances Accumulation in Lettuce: Effects of Cultivar, Growth Stage, and Cultivation Conditions on Food Safety

Horticulturae
Poly- and perfluoroalkyl substances (PFAS) are environmentally persistent contaminants that pose growing food safety concerns due to their potential for accumulation in edible crops.
Andrea Sabia, Ilaria Battisti, Anna Rita Trentin, Xudong Wei, Carlo Nicoletto, Giancarlo Renella, Antonio Masi   +6 more
doaj   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source