Results 51 to 60 of about 29,416 (304)

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate

Toxics, 2022
Perfluorooctane sulfonate (PFOS) is a typical persistent organic pollutant and environmental endocrine disruptor that has been shown to be associated with the development of many diseases; it poses a considerable threat to the ecological environment and ...
Pingwei Wang, Dongge Liu, Shuqi Yan, Yujun Liang, Jiajing Cui, Li Guo, Shuping Ren, Peng Chen   +7 more
doaj   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Fast PFAS determination in honey by direct probe electrospray ionization tandem mass spectrometry: A health risk assessment insight

Open Chemistry
Per- and polyfluoroalkylated substances (PFAS) are a group of anthropogenic chemicals used in a multitude of applications. Nevertheless, PFAS are considered emerging contaminants, posing significant threats to human health as a consequence of their ...
Tzanetou Evangelia N., Vousaxaki Efstathia, Machera Kyriaki, Kasiotis Konstantinos M.   +3 more
doaj   +1 more source

Human liver perfluorooctane sulfonate associates with steatotic liver disease in a sex-dependent manner

Environment International
Perfluorooctane sulfonate (PFOS) is a persistent and widespread contaminant found in the environment and, as a consequence, in the human body, and is linked to adverse health effects, including steatotic liver disease (SLD).
Emily Flam, Viktor Liénard, Violeta Raverdy, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond, Philippe Lefebvre, François Pattou, Delphine Eberlé, Joel T. Haas, Bart Staels   +10 more
doaj   +1 more source

Perfluorooctane sulfonate promotes atherosclerosis by modulating M1 polarization of macrophages through the NF-κB pathway

Ecotoxicology and Environmental Safety, 2023
Perfluorooctane sulfonate (PFOS) is a widely used and distributed perfluorinated compounds and is reported to be harmful to cardiovascular health; however, the direct association between PFOS exposure and atherosclerosis and the underlying mechanisms ...
Dan Wang, Zhenzhen Tan, Jing Yang, Longfei Li, Haoran Li, Huaxing Zhang, Heqiong Liu, Yi Liu, Lei Wang, Qian Li, Huicai Guo   +10 more
doaj   +1 more source

Profiling of Integrin Isoforms on Lung‐Tropic Exosomes by Spectrally and Kinetically Multiplexed Single‐Molecule Imaging

Advanced Science, EarlyView.
A spectrally and kinetically multiplexed single‐molecule imaging method is developed, which achieved simultaneous imaging of 12 exosomal proteins at an unparalleled single‐copy resolution. It is found that co‐occurrence of α6 integrin and the pairing β counterpart on single exosomes is essential for lung targeting, providing valuable information for ...
Songlin Liu, Haixin Wang, Qin Shentu, Liang Yuan, Jiangshan Tie, Li Li, Rui Ai, Bochen Ma, Lubin Qi, Yifei Jiang, Xiaohong Fang   +10 more
wiley   +1 more source

Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data

Hygiene and Environmental Health Advances, 2023
Background: Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese population ...
Yun-Ting Zhang, Huihui Bao, Lei Zhang, Sheng Wen, Weihong Tan, Mohammed Zeeshan, Ming-Kun Sun, Chu Chu, Zhao-Huan Gui, Li-Zi Lin, Ru-Qing Liu, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Dong   +13 more
doaj   +1 more source

Nonideal Transport and Extended Elution Tailing of PFOS in Soil.

Environmental Science and Technology, 2019
The objective of this research was to examine the influence of nonideal sorption/desorption on the transport of polyfluorinated alkyl substances (PFASs) in soil, with a specific focus on characterizing and quantifying potential extended, mass-transfer ...
M. Brusseau, N. Khan, Yake Wang, N. Yan, Sarah Van Glubt, K. Carroll   +5 more
semanticscholar   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source