Results 111 to 120 of about 51,376 (264)

Screening of Brazilian Isolated Yeasts Reveals Multiple Potential Chassis for Industrial Biotechnology

open access: yesYeast, EarlyView.
Harnessing Brazilian microbial diversity, comprehensive phenotypic screening of 79 yeast isolates identified non‐conventional strains with superior multi‐stress tolerance and metabolic versatility compared to S. cerevisiae under industrially relevant conditions.
Giovanna R. Maklouf   +10 more
wiley   +1 more source

MOEA/D‐based multi‐row facility layout optimisation method with discontinuity perceiving of the Pareto front

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
Abstract In a multi‐row facility layout problem (MRFLP), facilities are arranged in more than one row under the limited layout area. Considering different layout factors, various extensions of MRFLP have been modelled. However, the orientation of input/output (I/O) point in a facility, as a key factor that plays a direct impact on flow cost, is seldom ...
Yinan Guo   +5 more
wiley   +1 more source

Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley   +1 more source

Effect of Anti‐IL‐23 and Anti‐IL‐17 Therapy on Darier Disease: A Case Series

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Darier disease is a rare ATP2A2‐related genodermatosis for which therapeutic options remain limited, as acitretin is often constrained by toxicity and teratogenicity. In this retrospective real‐world case series of eight patients, anti‐IL‐17 therapy showed a more consistent early signal of clinical benefit than anti‐IL‐23 therapy, with greater
Maione Vincenzo   +6 more
wiley   +1 more source

Bacterial production of poly-γ-glutamic acid and evaluation of its effect on the viability of probiotic microorganisms [PDF]

open access: yes, 2012
A thesis submitted for the degree of Doctor of Philosophy By Aditya Bhat, MScPoly-γ-glutamic acid (γ-PGA) is a naturally occurring biopolymer made up of repeating units of glutamic acid and can be potentially used for multiple applications.
Bhat, Aditya
core  

Dupilumab‐Associated Erythema Multiforme‐Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Dupilumab‐associated erythema multiforme and lichenoid eruptions have been previously reported as rare dermatological adverse events. We present an atypical paediatric case of a dupilumab‐associated erythema multiforme‐like eruption in a 5‐year‐old male eczema patient, who developed erythematous targetoid papules and plaques over the upper and
Paul Sun Woo Kim   +7 more
wiley   +1 more source

Dupilumab in Paediatric Netherton Syndrome: Two Case Reports and a Review of the Literature

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Netherton Syndrome (NS) is a rare genodermatosis characterised by a triad of ichthyosiform erythroderma, an atopic diathesis, and trichorrhexis invaginata, for which no effective management is currently approved in Australia. Dupilumab has demonstrated considerable effectiveness in the treatment of atopic conditions in the paediatric ...
Jacqueline Tu   +5 more
wiley   +1 more source

Improving ARTs: Microfluidics as a Tool for Sperm Selection

open access: yesAndrology, EarlyView.
ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez   +7 more
wiley   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

open access: yesBritish Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco   +8 more
wiley   +1 more source

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