Results 111 to 120 of about 33,493 (201)

Vascular and skeletal muscle oxidative capacity responses to continuous double and single leg cycling

Experimental Physiology, EarlyView.
Abstract The purpose of this work was to determine endothelial, microvascular, skeletal muscle oxidative capacity (SMOC) and cardiorespiratory responses to an acute bout of continuous single leg cycling (SLC) and double leg cycling (DLC). Ten recreationally active men and women volunteered to participate in this investigation and reported to the ...
Edward Z. Pelka, B. Ryan Davis, John McDaniel   +2 more
wiley   +1 more source

PGC-1α agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. [PDF]

Blood Adv
Benmhammed H, Sun Y, AlAbdullatif S, Chen A, Khan S, Zadeh AM, Mazile N, Beacham GM, Mahdaviani K, Williams C, Alekseyev YO, Campbell JD, Hagedorn EJ, Heaphy C, Klings ES, Steinberg MH, Cui S.   +16 more
europepmc   +1 more source

Impact of 14 days of head‐down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults

Experimental Physiology, EarlyView.
Abstract Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults.
Jean‐Christophe Lagacé, Philippe St‐Martin, Mariano Avino, Ahmed Ghachem, Guy Hajj‐Boutros, Jose A. Morais, Jamie S. McPhee, Karen Lambert, Eléonor Riesco, Isabelle J. Dionne   +9 more
wiley   +1 more source

(Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance

Experimental Physiology, EarlyView.
Abstract (Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant‐ and animal‐based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti‐inflammatory and vasodilatory.
Glyn Howatson, Tom Clifford
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

m6A-Mediated epitranscriptional reprogramming drives cardiac fibrosis by suppressing PGC-1α and boosting mitochondrial fission. [PDF]

J Transl Med
Cao XY, Tu B, Cao ZR, Liu F, Yan G, Dong J, Huang QW, Li ZJ, Liu QY, Leng JJ, Yu WC, Bie MJ, Wang XW, Jiang YJ.   +13 more
europepmc   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

BVDV utilizes PGC-1α downregulation to remodel the mitochondrial metabolic microenvironment, enhancing viral replication and impairing host immunity. [PDF]

Front Vet Sci
Zhou H, Zhao Y, Kong Y, Yin J, He N, Wang Q, Liu J, Zhou T, Han Y, Dong S, Zhao Y, Diao N, Shi K, Du R.   +13 more
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Irisin-Driven AMPK-PGC-1α Activation Underlies the Renoprotective Effects of Swimming Exercise in Obesity-Induced Kidney Injury. [PDF]

Biomolecules
Hanafy SM, Zakaria SS, Jumaa MI, Al-Dhelaan RA, Yousef EM.   +4 more
europepmc   +1 more source