Results 151 to 160 of about 33,493 (201)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Remote Ischemic Preconditioning Exerts Neuroprotective Effects Via the PGC-1α/FNDC5/BDNF Pathway in Focal Brain Ischemia of Rats. [PDF]

Transl Stroke Res
Matsuoka T, Matsuzaki R, Nakanishi K, Kakimoto S, Kato Y, Otsuka S, Kikuchi K, Sakakima H.   +7 more
europepmc   +1 more source

The role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury

British Journal of Pharmacology, Volume 183, Issue 13, Page 3815-3828, July 2026.
Abstract Background and Purpose Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.
Ilter Ilhan, Halil Aşcı, Muhammet Yusuf Tepebasi, Nursel Hasseyid, Melih Arlıoğlu, Özlem Özmen   +5 more
wiley   +1 more source

Modulation of the miR-485-3p/PGC-1α Pathway by ASO-Loaded Nanoparticles Attenuates ALS Pathogenesis. [PDF]

Int J Mol Sci
Ryu IS, Ha DI, Jung YJ, Lee HJ, Kim I, Lim YN, Min HS, Kim SH, Yoon I, Cho HJ, Ryu JH.   +10 more
europepmc   +1 more source

Architecture of lower leg muscles in children: Reference curves and potential mechanisms of growth

Journal of Anatomy, Volume 249, Issue 1, Page 54-67, July 2026.
Muscle architecture (physiological cross‐sectional area, fascicle lengths and pennation angle) was measured from multimodal MRI scans of the lower legs of 197 children aged ≤15 years. We showed that lower leg muscle volumes (product of PCSA and fascicle length) increase primarily through increases in PCSA (transverse growth) rather than increases in ...
Brian V. Y. Chow, Suzanne Davies, Catherine Morgan, Caroline D. Rae, David I. Warton, Iona Novak, Ann Lancaster, Gordana C. Popovic, Rodrigo R. N. Rizzo, Claudia Y. Rizzo, Iain K. Ball, Robert D. Herbert, Bart Bolsterlee   +12 more
wiley   +1 more source

Microglial PGC-1α alleviates synaptic damage and cognitive impairments following anesthesia and surgery by suppressing excessive synaptic pruning in aged mice. [PDF]

Int J Biol Sci
Wu X, Xu M, Huang Y, Chen P, Wu L, Chen A, Wei J, Chen Y, Lin Y, Lin Y, Lin Z, Lin Y, Xue F, Chen X, Zheng X.   +14 more
europepmc   +1 more source

Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Obesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT This systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted to assess the effect of nutraceuticals containing Citrus bergamia on the management of obesity in adults by assessing measures related to obesity. We searched the following databases until October 2024: PubMed, Web of Science, Scopus, and the Cochrane
Carmelo Pujia, Yvelise Ferro, Alberto Castagna, Elisa Mazza, Samantha Maurotti, Francesca Rita Noto, Valeria Rizzo, Tiziana Montalcini, Arturo Pujia   +8 more
wiley   +1 more source

Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]

Food Sci Nutr
Zhu J, Peng F, Zhang L, Guo Y, Liu W, Li J, Shang S, Zhang B, Qiu T.   +8 more
europepmc   +1 more source

Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles That Promote Angiogenesis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles that Promote Angiogenesis. The results from this study suggest that EVs isolated from blood immediately after the last bout of endurance exercise training (ExerV) are enriched in antioxidants. ExerVs stimulate vascular growth both in vitro and in 
Alexander M. Fliflet, Ray A. Spradlin, Yanqi Tan, Ane Nishitha Vijayan, Sung Jun Choi, Wei‐Chun Kao, Edita Aksamitiene, Michael Nelappana, Shengzhe Ding, Kai‐Yu Huang, Aryaman Joshi, Nurila Kambar, Tom Bludgen, Madeleine Meehan, Jayna L. Boss, Michael Knipp, Hongming Fan, Cecilia Leal, Roger A. Sunde, Lawrence W. Dobrucki, Stephen A. Boppart, Hyun Joon Kong, Jonathan V. Sweedler, Marni D. Boppart   +23 more
wiley   +1 more source

PACAP Alleviates Paclitaxel-Induced Peripheral Neuropathy by Targeting Oxidative Stress and Mitochondrial Damage via the PGC-1α Pathway. [PDF]

CNS Neurosci Ther
Mo R, Wang C, Hu H, Shi S, Cao D, Luo Z, Yang H, Zhai M, Sun W.   +8 more
europepmc   +1 more source