Results 141 to 150 of about 33,493 (201)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Adipocyte-Derived Extracellular Vesicles Endow Melanoma Cells with Stem-like Traits via PGC-1α-Mediated Mitochondrial Reprogramming. [PDF]

Antioxidants (Basel)
Giannitti G, Marchesi S, Garavaglia R, Preosto I, Carollo E, Sartori P, Fontana F.   +6 more
europepmc   +1 more source

Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38‐ATF3 Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Resveratrol dose‐dependently upregulates GDF15 expression in murine and human cells via the p38‐ATF3 signaling axis. In high‐fat diet fed mice, resveratrol elevates systemic and tissue GDF15 levels, thereby reducing food intake and weight gain and conferring resistance to diet‐induced obesity. This study identifies a novel p38‐ATF3‐GDF15 axis mediating
Liufeng Mao, Yunliang Hou, Weifang Liu, Jianbin Chen, Wanli Hu, Wengong Jiang, Tao Nie   +6 more
wiley   +1 more source

Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage. [PDF]

Biology (Basel)
Bai S, La X, Yang Y, Li Y, Wang D, Ren Y, Fang H, Li X, Song X, Cheng X, Xu D.   +10 more
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

<i>Dendrobium officinale</i> polysaccharide ameliorates high-fat diet-induced hepatic lipid metabolic disorder via the SIRT6/PGC-1α signaling axis. [PDF]

Front Nutr
Hu B, Yao L, Deng X, Zhao W, Chen K, Zhang J, Li Z, Li JP, Jiang W, Liu H.   +9 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

Engineered Tan-CDs@AS-IV Nanosystem Orchestrates Mitochondrial Biogenesis and Intercellular Transfer to Restore Endothelial Function via PGC-1α and Cx43 Signaling Pathways. [PDF]

Nanomaterials (Basel)
Wang H, Wang X, Liu S, Liu C.
europepmc   +1 more source

Tucum‐do‐Cerrado (Bactris setosa Mart.) Consumption Promoted a Healthier Expansion of Adipose Tissue in High‐Fat Diet‐Induced Obesity Rats

Molecular Nutrition &Food Research, Volume 70, Issue 13, 15 July 2026.
ABSTRACT Tucum‐do‐Cerrado (Bactris setosa Mart.) is a polyphenol‐rich Brazilian fruit known to improve glucose metabolism. This study investigated its effects on brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues in a diet‐induced obesity model. Rats received control (CT/TUC‐), high‐fat (HF/TUC‐), control with Tucum‐do‐Cerrado (CT/TUC+)
Marilia Hermes Cavalcanti, Amílcar Sabino Damazo, Sandra Fernandes Arruda   +2 more
wiley   +1 more source

Piperine improves ischemic brain injury by promoting the regulation of the AMPK/PGC-1α pathway by Apelin 13. [PDF]

Front Pharmacol
Xi S, Ma J, Yan J, Li Y, Zhang P, Chen H, Yang G, Fu X, Liu J, Zhang Y.   +9 more
europepmc   +1 more source