Results 171 to 180 of about 49,868 (226)

PACAP Alleviates Paclitaxel-Induced Peripheral Neuropathy by Targeting Oxidative Stress and Mitochondrial Damage via the PGC-1α Pathway. [PDF]

CNS Neurosci Ther
Mo R, Wang C, Hu H, Shi S, Cao D, Luo Z, Yang H, Zhai M, Sun W.   +8 more
europepmc   +1 more source

A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone‐Mediated C2C12 Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Skeletal muscle is a vital part of human physiology and is responsible for numerous essential functions. Not surprisingly, the loss of skeletal muscle mass and function is common in several pathologies including atrophy and sarcopenia, which profoundly impact quality of life of those afflicted.
Alexa J. Klein, Roger A. Vaughan
wiley   +1 more source

STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery. [PDF]

Eur J Med Res
Shen QH, Xia JY, Ma Y, Xu SS.
europepmc   +1 more source

Muscle Weakness and the Irisin–BDNF and Oxidative Stress Axis in the 60‐Day Pseudorandomised Controlled AGBRESA Bed Rest Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Muscle atrophy and weakness are among the most detrimental consequences of disuse, microgravity, hospitalisation and ageing. Oxidative modifications of myofibrillar proteins generated by oxidative stress may contribute to the reduced force‐ and power‐generating capacity of skeletal muscles. As part of the 60‐day AGBRESA bed rest (BR)
Alessandra Bosutti, Bergita Ganse, Edwin Mulder, Markus Gruber, Maria Venegas‐Carro, Jochen Zange, Jörn Rittweger, Moritz Eggelbusch, Rob C. I. Wüst, Paul Hendrickse, Hans Degens   +10 more
wiley   +1 more source

Remdesivir may exacerbate ischemic acute kidney injury through molecular alterations in PGC-1α and apoptosis pathways: An in vivo study. [PDF]

PLoS One
Bagheri Y, Malekinejad Z, Hejazian SM, Abdollahpour A, Khajepour F, Farahbod M, Ahmadi S, Matin S, Zununi Vahed S.   +8 more
europepmc   +1 more source

Mitochondrial Adaptations in Skeletal Muscle Following Incretin‐Based Therapies: In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Incretin‐based therapies such as glucagon‐like peptide‐1 receptor agonists (GLP‐1Ras), dual GLP‐1/GIP agonists and amylin analogues have demonstrated significant weight loss benefits. However, their impact on skeletal muscle mitochondrial function, particularly under metabolic stress, remains unclear. This study aimed to investigate
Victoria Old, Melanie Davies, Matthew Denniff, Pratik Choudhary, Nicholas Eastley, Robert U. Ashford, Emma Watson   +6 more
wiley   +1 more source

Skeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis. [PDF]

J Cachexia Sarcopenia Muscle
Karasawa T, Choi RH, Meza CA, Watanabe S, Maschek JA, Nikolova LS, Cox JE, Funai K.   +7 more
europepmc   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response. [PDF]

CNS Neurosci Ther
Hu Z, Pang J, Liu X, Zhao Y, Lu Y, Chen H, Zeng H, Yu Y, Zhao Y, Gao L, Zhang X, Jin J, Wang K, Shi Y, Zhan H, Wu W.   +15 more
europepmc   +1 more source

Elevated Kallistatin Induces Myosteatosis and Exercise Intolerance by Antagonizing AdipoR1‐Mediated AMPK Signalling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Pathological intramuscular lipid deposition (myosteatosis) and exercise intolerance are hallmarks of metabolic disorders, including diabetes and metabolic dysfunction‐associated steatotic liver disease (MASLD), yet their underlying mechanisms remain unclear.
Fuyan Hong, Zhenzhen Fang, Gang Shen, Yan Wang, Yunhua Li, Youbin Zhong, Junze Dai, Chengwei Zhang, Jing Zhang, Wencan Chen, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou   +13 more
wiley   +1 more source