Results 171 to 180 of about 122,171 (336)

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti   +10 more
wiley   +1 more source

Exploring the Activation of the Keap1‐Nrf2‐ARE Pathway by PAHs in Children's Toys

open access: yesContact Dermatitis, EarlyView.
Our study evaluated the skin sensitisation risk of polycyclic aromatic hydrocarbons (PAHs) in toys, revealing that B[k]F, B[b]F and chrysene are highly potent sensitizers. Synergistic effects in PAH mixtures underscore the need to consider combined exposures when assessing environmental risks to children.
Jonas Lauenstein   +6 more
wiley   +1 more source

PGE2 and the innate immune response

open access: yes, 2015
Resumen del trabajo presentado al 12th World Congress on Inflammation, Symposium 3: Disease Modification in Osteoarthritis: Myth or Reality?; celebrado en Boston (US) del 8 al 12 de agosto de 2015.
openaire   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

open access: yesCell Proliferation, EarlyView.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei   +5 more
wiley   +1 more source

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma [PDF]

open access: yes, 2017
Das, Sunit   +9 more
core   +3 more sources

Mitonuclear Communication in Stem Cell Function

open access: yesCell Proliferation, EarlyView.
In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley   +1 more source

Continuous-flow biosynthesis of prostaglandin E2 (PGE2).

open access: bronze, 1985
Toro Nakahara   +5 more
openalex   +2 more sources

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