Results 171 to 180 of about 89,482 (299)

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Unique/Rapid Feedback Mechanisms of PGD₂ and PGE₂ as Local/Short-Lived Autacoids; Implications of Biased Activities by Their Metabolites. [PDF]

Bioessays
Fujino H, Fukushima K.
europepmc   +1 more source

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

Targeting Lipid Metabolic Reprogramming to Overcome Immunotherapy Resistance: Systemic Nutritional Modulation and Precision Nanomedicine. [PDF]

Int J Nanomedicine
Li Q, Yang J, Chen D, Chen Y, Jiang S.
europepmc   +1 more source

Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG

The Journal of Physiology, EarlyView.
Abstract figure legend In addition to widespread pain and fatigue, people with fibromyalgia (FM) experience sensory abnormalities and report lingering, painful sensations after touch or mechanical probing of the skin. Administration of IgG purified from FM patients to mice transfers symptoms and signs of FM.
Mathilde R. Israel, Nisha Vastani, Clive Gentry, Andreas Goebel, Stuart Bevan, David A. Andersson   +5 more
wiley   +1 more source

Pro-Angiogenic Response to OsteoBiol^® GTO^® in an In Vitro Endothelial Cell Model Is Associated with Modulation of the COX-2/PGE2/VEGF Axis. [PDF]

Bioengineering (Basel)
Ricci A, Romasco T, Balaha M, Piattelli A, Cataldi A, Di Pietro N, Zara S.   +6 more
europepmc   +1 more source

Circulating microRNA signatures reveal core and reversible dysregulation in obesity via machine learning

The Journal of Physiology, EarlyView.
Abstract figure legend Machine learning analysis of circulating microRNA (miRNA) profiles identified a minimal set of biomarkers that distinguish individuals with obesity from lean individuals both before and after weight‐loss intervention. Comparative analyses revealed heterogeneous molecular responses to weight reduction, with some miRNAs showing ...
Yuan Yue, Rajesh Katare, Jeremiah Deng, Daniel Alencar Da Costa, Patrick Manning   +4 more
wiley   +1 more source

Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition. [PDF]

Front Immunol
Vidal-Manrique M, Hooijmaijers L, Teders JAJ, Saf E, Klarenbeek K, Hagemans IM, Cuenca-Escalona J, Cambi A, de Vries IJM, de Jonge PKJD, van der Waart AB, Dolstra H.   +11 more
europepmc   +1 more source

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Endothelin-1 drives COX-2 and prostaglandin E₂ expression in osteoblasts through MAPK/AP-1 signaling during periodontal inflammation. [PDF]

J Dent Sci
Fan FY, Vo TTT, Kuo H, Tseng CF, Lin WN, Wu CY, Wu YC, Yang CM, Hsiao LD, Lee IT.   +9 more
europepmc   +1 more source