Results 281 to 290 of about 133,795 (342)

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

The Myeloid Biomarker <i>MS4A6A</i> Drives an Immunosuppressive Microenvironment in Glioblastoma via Activation of the PGE2 Signaling Axis. [PDF]

Int J Mol Sci
Chen J, Wu Q, Berglund AE, Macaulay RJ, Mulé JJ, Etame AB.   +5 more
europepmc   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

GluN2A-NMDAR mediated neuronal NFκB activation plays a key role in exacerbating ischemic brain injury under hyperhomocysteinemic conditions. [PDF]

J Cereb Blood Flow Metab
Seelig S, Paramasivam P, Gomez M, Smith A, Miller JW, Paul S, Poddar R.   +6 more
europepmc   +1 more source

PS49. Shifted Circadian Phase in Manic Episode was Returned to Normal after Treatment in Bipolar Disorder [PDF]

, 2016
Cho, Chul-Hyun, Chung, Sooyoung, Geum, Dongho, Hyonggin, An, Jee, Hee-Jung, Kang, Seung-Gul, Kim, Hyun, Kim, Leen, Kripke, Daniel F, Lee, Heon-Jeong, Moon, Joung-Ho, Park, Young-Min, Son, Gi Hoon, Yoon, Ho-Kyoung   +13 more
core  

PGE2 regulatory effect on TNF-α and IL-17 production on microbicidal activity in canine leishmaniasis.

, 2019
Gabriela Lovizutto Venturin
openalex   +1 more source

Targeting neutrophil‐driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning, Ke Lei, Xinyan Gao, Yan Kong, Yuping Shan, Tian Tian, Zhumei Cui, He Ren   +7 more
wiley   +1 more source

Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives.
Isabel Sousa Alcântara, Renata Torres Pessoa, Lucas Yure Santos da Silva, Tarcisio Mendes Silva, Isis Oliveira Menezes, Anita Oliveira Brito Pereira Bezerra Martins, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley   +7 more
wiley   +1 more source

Prostaglandin E2 as a Mechanistic Biomarker of Chronic Pancreatitis. [PDF]

Clin Transl Gastroenterol
Saloman JL, Jefferson B, Han S, Fisher WE, Fogel EL, Hart PA, Li L, Park WG, Vege SS, Yadav D, Topazian MD, Conwell DL, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).   +14 more
europepmc   +1 more source

Exploiting Lactic Acid Bacteria for Regulating Autophagy to Improve Health in Foods and Supplements: A Recent Update

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Lactic acid bacteria (LAB) are frequently used as health supplements. They enhance digestion, regulate immunity, improve gut microbiota, and prevent and manage diseases. Autophagy has a crucial role in the prevention and treatment of tumors, cardiovascular diseases, and pathogenic infections.
Yang Chen, Fangyi Chen, Mengchen Li, Junfeng Xiao, Yang Mu, Chao Wang, Lusha Xia, Mingye Peng, Mengzhou Zhou   +8 more
wiley   +1 more source