Results 311 to 320 of about 133,795 (342)
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Prostaglandins, 1975
The biological activities of 8,12-diiso-PGE2 (ent-11,15-epi-PGE2), PGE2 and PGF2alpha have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF2alpha but unlike PGE2, 8,12-diiso-PGE2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig
R, Ceserani +3 more
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The biological activities of 8,12-diiso-PGE2 (ent-11,15-epi-PGE2), PGE2 and PGF2alpha have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF2alpha but unlike PGE2, 8,12-diiso-PGE2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig
R, Ceserani +3 more
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Antifertility effects of PGE2 and PGF2α
Contraception, 1974Abstract The effectiveness of prostaglandins to modify egg transport, to stimulate uterine contractility and to induce luteolysis suggested their possible role as postcoital contraceptives. PGE 2 and PGF 2α were injected at 24 hours postcoitum (h p.c.) or at 4 days postcoitum (d p.c.) in rabbits. Effects on fertility were studied at autopsy 14 d p.c.
I, Aref, G H, Gottschewski, E S, Hafez
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Receptor binding in various tissues of PGE2, PGF2α and sulprostone, a novel PGE2-derivative
Prostaglandins, 1979Sulprostone is a tissue-specific PGE2-derivative with high abortifacient activity in various species including man. The dissociation constant KD of the receptor binding of this compound was compared with PGE2 and PGF2 alpha in various tissue preparations of different species.
E, Schillinger +3 more
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Prostaglandins, 1981
Normal conscious female Sprague-Dawley rats were treated with chlorazanil (3 mg/kg i.p.), and urine was collected for 3 hours. Urine prostaglandin E2-excretion increased from 25 +/- 3 to 271 +/- 32 ng/kg/3 h. The enhancement of urine PGE2-excretion was inhibited by pretreatment with bumetanide (75 mg/kg p.o.).
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Normal conscious female Sprague-Dawley rats were treated with chlorazanil (3 mg/kg i.p.), and urine was collected for 3 hours. Urine prostaglandin E2-excretion increased from 25 +/- 3 to 271 +/- 32 ng/kg/3 h. The enhancement of urine PGE2-excretion was inhibited by pretreatment with bumetanide (75 mg/kg p.o.).
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Plasma levels of 13,14-dihydro-15-keto PGE2 after vaginal application of a new PGE2 film
Prostaglandins, 1985To determine the release and absorption profile of prostaglandin E2 from a new vaginal film formulation containing 850 micrograms PGE2, serial plasma levels of 13,14-dihydro-15-keto PGE2 were measured by radioimmunoassay in pregnant women between 16 and 18 weeks gestation. A control group, using placebo vaginal film was included in the study. There was
R N, Prasad +4 more
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EGF and PGE2 inhibit rabbit CCD Na+ transport by different mechanisms: PGE2 inhibits Na(+)-K+ pump
American Journal of Physiology-Renal Physiology, 1993The rabbit cortical collecting duct absorbs Na+ by a transport system comprised of an apical membrane Na+ channel and a basolateral membrane Na(+)-K(+)-adenosinetriphosphatase. The rate of Na+ absorption across this epithelium is acutely inhibited by several hormones and autacoids including epidermal growth factor (EGF) and prostaglandin E2 (PGE2). We
D H, Warden, J B, Stokes
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Synthesi of (–)-PGE2 Methyl Ester
1997Abstract Discussion Points Propose a structure for the reactive intermediate formed in step g before the addition of water. Treating intermediate 7 with benzoic acid resulted in the formation of compound 17. Suggest a structure for 7 and the mechanisms by which it gave both diazoketone 10 and benzoate ester 17.
D F Taber, R S Hoerrner,
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Science Translational Medicine, 2014
By chelating bioactive PGE2, a molecule with immunosuppressive properties, albumin helps preserve normal immune function.
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By chelating bioactive PGE2, a molecule with immunosuppressive properties, albumin helps preserve normal immune function.
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Gastroenterology, 1976
15-Methyl PGE2 and 16,16-dimethyl PGE2 were found (1) to be 40 and 100 times, respectively, more potent than PGE2 after intravenous administration in inhibiting histamine-stimulated gastric secretion in dogs with a denervated (Heidenhain) gastric pouch, (2) to be active orally and intrajejunally, whereas PGE2 was inactive, and (3) to exert ...
A, Robert +3 more
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15-Methyl PGE2 and 16,16-dimethyl PGE2 were found (1) to be 40 and 100 times, respectively, more potent than PGE2 after intravenous administration in inhibiting histamine-stimulated gastric secretion in dogs with a denervated (Heidenhain) gastric pouch, (2) to be active orally and intrajejunally, whereas PGE2 was inactive, and (3) to exert ...
A, Robert +3 more
openaire +1 more source