Results 111 to 120 of about 296,899 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Amphoteric Soy Protein-Rich Fibers for Rapid and Selective Adsorption and Desorption of Ionic Dyes. [PDF]

, 2020
Uniquely amphoteric soy protein (SP)-rich ultra-fine fibers (231 nm average diameter) have been facilely electrospun from aq. colloids and rendered water-insoluble by heating (150 °C, 12 h) to be highly stable over 14 d (pH 7) as well as under extremely ...
Hsieh, You-Lo, Liu, Xingchen
core  

Tuning the aggregation behavior of pH-responsive micelles by copolymerization [PDF]

, 2015
YesAmphiphilic diblock copolymers, poly(2-(diethylamino)ethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate), P(DEAEMA-co-DMAEMA)-b-PDMAEMA with various amounts of DEAEMA have been synthesized by RAFT ...
Anaïs Pitto-Barry, Bendejacq, Bendejacq, Charbonneau, Charbonneau, Chassenieux, Choi, Choi, Christophe Chassenieux, Colombani, Cotanda, Creutz, Daniel B. Wright, Dutertre, Flory, Glatter, Guinier, Haag, Hamley, Hamley, Hayward, Hu, Hu, Jacquin, Jakes, Jiang, Joseph P. Patterson, Keddie, Kline, Lee, Lee, Lee, Lejeune, Lejeune, Lu, Lu, Lund, Lutz, Lutz, Moad, Nicolai, Olivier Colombani, Park, Patterson, Pepa Cotanda, Petzetakis, Picidn, Rachel K. O'Reilly, Roe, Sedlak, Sedlak, Shedge, van de Wetering, Van Herk, van Stam, Wang   +55 more
core   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles

Food Science and Human Wellness
In this paper, tannic acid (TA) and Fe3+ were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots (CQDs) encapsulating phlorotannins (PTN).
Qile Xia, Yan Liang, Ailing Cao, Yan Cao, Luyun Cai   +4 more
doaj   +1 more source

PEG–Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers [PDF]

, 2014
Herein we report the potential of click chemistry-modified polypeptide-based block copolymers for the facile fabrication of pH-sensitive nanoscale drug delivery systems. PEG–polypeptide copolymers with pendant amine chains were synthesized by combining N-
Aluri S., Bally M. B., Bellomo E. G., Bonduelle C., Bromley E. H. C., Chen C. Y., Chen W., Choi C. H. J., Chopko C. M., Deming T. J., Deming T. J., Engler A. C., Engler A. C., Ganta S., Harrigan P. R., Huang J., Huang J., Kataoka K., Kevin E. Shopsowitz, Lu J., Madden T. D., Mellman I., Mohiuddin A. Quadir, Morton S. W., Paula T. Hammond, Peer D., Petros R. A., Quadir M., Ryan P. Murphy, Sanson C., Schroeder A., Sonawane N. D., Stephen W. Morton, Thomas H. Epps, Upadhyay K. K., Upadhyay K. K., Wang A. Z., Whitehead K. A., Yin H., Zhou J. Deng, Zhou K.   +40 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

PH-Responsive Schizophrenic Diblock Copolymers Prepared by Polymerization-Induced Self-Assembly [PDF]

, 2017
Polymerization-induced self-assembly (PISA) is used for the highly convenient and efficient preparation of ampholytic diblock copolymer nanoparticles directly in acidic aqueous solution. Cationic nanoparticles comprising a protonated polyamine stabilizer
Armes, S.P., Canning, S.L., Neal, T.J.
core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source