Results 31 to 40 of about 2,076,410 (301)

Evaluation of dynamic peptide nanorods as a unique pH-dependent cell-penetrating agent

Discover Polymers
Target-specific strategies are essential for the success of modern drug therapy in terms of safety and effectiveness. Thus, drug delivery must extend beyond tissue-level targeting to intracellular targeting, which is the ultimate site of action.
Philipp Sonntag, Mohamed A. M. Kamal, Camilla Passi, Justine Bassil, Brigitta Loretz, Claus-Michael Lehr, Sangeun Lee   +6 more
doaj   +1 more source

Characterization and Equilibrium Study of Drug Release of pH-Responsive Chitosan-graft-Maleic Film

International Journal of Technology, 2022
    This paper reports on a pH responsive material and a mathematical model for a drug release study. This material can be applied as a tumor drug carrier, because the tumor tissue has a different pH (5.7–7.8) compared to the ...
Daniel Timotius, Yuni Kusumastuti, Rochmadi Rochmadi   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The pH-responsive precipitation–redissolution of the CspB fusion protein, CspB50TEV-Teriparatide, triggered by changes in secondary structure

Biochemistry and Biophysics Reports, 2023
Cell surface protein B (CspB) fusion proteins can undergo reversible pH-responsive precipitation–redissolution. A pH-responsive precipitation–redissolution of CspB tag purification (pPRCP) method was established for protein purification using this ...
Hayato Nagano, Teruhisa Mannen, Yoshimi Kikuchi, Kentaro Shiraki   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles

Drug Design, Development and Therapy, 2020
Yun Bian,1 Dong Guo2 1Department of Pharmacy, Affiliated Hospital of Jiangnan University, The Fourth People’s Hospital of Wuxi City, WuXi 214000, Jiangsu Province, People’s Republic of China; 2Affiliated Hospital of Jiangnan University, The ...
Bian Y, Guo D
doaj  

pH-Responsive Polymer Nanomaterials for Tumor Therapy

Frontiers in Oncology, 2022
The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery
Shunli Chu, Xiaolu Shi, Ye Tian, Fengxiang Gao   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy

International Journal of Nanomedicine, 2020
Yanhua Jiang,1 Yongjian Zhou,1 Can Yang Zhang,2 Te Fang1 1Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Singapore-MIT Alliance for Research and Technology ...
Jiang Y, Zhou Y, Zhang CY, Fang T
doaj  

pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

, 2017
In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented.
Chen, Hsin-Hung;Huang, Wen-Chia;Chiang, Wen-Hsuan;Liu, Te-I;Shen, Ming-Yin;Hsu, Yuan-Hung;Lin, Sung-Chyr;Chiu, Hsin-Cheng
core   +1 more source