Results 61 to 70 of about 296,899 (292)

Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy

International Journal of Nanomedicine, 2020
Yanhua Jiang,1 Yongjian Zhou,1 Can Yang Zhang,2 Te Fang1 1Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Singapore-MIT Alliance for Research and Technology ...
Jiang Y, Zhou Y, Zhang CY, Fang T
doaj  

Dialysis Preparation of Smart Redox and Acidity Dual Responsive Tea Polyphenol Functionalized Calcium Phosphate Nanospheres as Anticancer Drug Carriers

Molecules, 2020
Large-scale preparation of biocompatible drug delivery systems with targeted recognition and controlled release properties has always been attractive. However, this strategy has been constrained by a lot of design challenges, such as complicated steps ...
Xiuli Ren, Peng Zhang, Zhenhua Chen
doaj   +1 more source

Characterization of pH-responsive Genes in Cryptococcus Neoformans [PDF]

, 2019
Undergraduate ...
John, Kristen
core   +1 more source

CO2/pH-responsive particles with built-in fluorescence read-out [PDF]

, 2016
yesA novel fluorescent monomer was synthesized to probe the state of CO2-responsive cross-linked polymeric particles. The fluorescent emission of this aminobromomaleimide-bearing monomer, being sensitive to protic environments, can provide information on
Abel, Anaïs Pitto-Barry, Anne B. Mabire, Chen, Chen, Cobo, Dai, Darabi, Emma Chapman, Gibson, Girard, Helen Willcock, Hill, Hoshino, Li, Li, Lin, Liu, Mabire, Mabire, Morse, Nigel Kirby, Patterson, Pinaud, Quek, Quentin Brouard, Rachel K. O'Reilly, Rebecca J. Williams, Robin, Robin, Robin, Robin, Robin, Salentinig, Schattling, Shahalom, Tan, Theato, Walker, Wang, Wright, Wright, Xiao, Yan, Yan   +44 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Breathing Life into Polycations [PDF]

, 2008
The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin, Oskuee, Reza, Philipp, Alexander, Schmidt, Claudia, Wagner, Ernst   +4 more
core   +1 more source

Mechanics of pH-Responsive Hydrogel Capsules [PDF]

Langmuir, 2013
While soft hydrogel nano- and microstructures hold great potential for therapeutic treatments and in vivo applications, their nanomechanical characterization remains a challenge. In this paper, soft, single-component, supported hydrogel films were fabricated using pendant-thiol-modified poly(methacrylic acid) (PMASH).
Best, JP, Neubauer, MP, Javed, S, Dam, HH, Fery, A, Caruso, F   +5 more
openaire   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance

Drug Delivery, 2018
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance.
Weihong Guo, Lizhi Deng, Jiang Yu, Zhaoyu Chen, Yanghee Woo, Hao Liu, Tuanjie Li, Tian Lin, Hao Chen, Mingli Zhao, Liming Zhang, Guoxin Li, Yanfeng Hu   +12 more
doaj   +1 more source