Results 271 to 280 of about 7,285,451 (331)

A Low-Friction Capsule Robot with Drive-Control-Sensing Integration for Gastrointestinal Lesion Detection. [PDF]

Research (Wash D C)
Wang Z, Yin H, Wei Z, Chen S, Li J, Sun J, Zhao W, Jia Y.   +7 more
europepmc   +1 more source

Neural Network Adaptive Control With Long Short‐Term Memory

International Journal of Adaptive Control and Signal Processing, EarlyView.
ABSTRACT In this study, we propose a novel adaptive control architecture that provides dramatically better transient response performance compared to conventional adaptive control methods. This is accomplished by the synergistic employment of a traditional adaptive neural network (ANN) controller and a long short‐term memory (LSTM) network.
Emirhan Inanc, Abdullah Habboush, Yigit Gurses, Yildiray Yildiz, Anuradha M. Annaswamy   +4 more
wiley   +1 more source

Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike. [PDF]

Commun Biol
Glas I, Zimmermann L, Luo B, Pohl MO, Wrobel AG, Schaub A, Klein LK, David SC, Gaggioli E, Bluvshtein N, Huber M, Nenes A, Krieger UK, Peter T, Kohn T, Chlanda P, Stertz S.   +16 more
europepmc   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Membrane-dependent assembly of Bruton's tyrosine kinase mediated by the Proline-rich region and SH3 domain. [PDF]

Protein Sci
Fenton AD, Chung JK.
europepmc   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension. [PDF]

Pulm Circ
Reiser AE, Thiersch M, Gassmann M, Muckenthaler MU, Geiser T, Lichtblau M, Ulrich S.   +6 more
europepmc   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source