Results 61 to 70 of about 1,571,058 (290)

Estimation of N2O emission factors for soils depending on environmental conditions and crop management [PDF]

, 2009
Nitrous oxide (N2O) contributes 8% to anthropogenic global warming, of which about one third are direct emissions of agricultural soils. These N2O emissions are often estimated using the default IPCC 2006 emission factor of 1% of the amount of N applied ...
Lesschen, J.P., Velthof, G.L.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Does Long-Term Macrophyte Management in Lakes Affect Biotic Richness and Diversity? [PDF]

, 2005
We hypothesize that the richness and diversity of the biota in Lake Moraine (42°50’47”N, 75°31’39”W) in New York have been negatively impacted by 60 years of macrophyte and algae management to control Eurasian watermilfoil ( Myriophyllum spicatum L.
Harman, Willard N., Hingula, L. P., Macnamara, C. E.   +2 more
core  

The Influence of the Zebra Mussel (Dreisena Polymorhpa) on Magnesium and Calcium Concentration in Water [PDF]

, 2010
In this study we examined changes in magnesium and calcium ion concentrations depending on Zebra Mussel biomass, pH values and temperature. We performed field experiments in years with different weather conditions using twelve 200 litre polycarbonate ...
Frankiewicz, Piotr, Wojtal-Frankiewicz, Adrianna   +1 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

MONITORING OF EXCHANGE RISK OF BANKS BASED ON THE CONSOLIDATED BALANCE SHEET INDEX

Фінансово-кредитна діяльність: проблеми теорії та практики, 2021
The paper deals with basic approaches to monitoring of the currency risk. The purpose of the paper is to substantiate the theoretical and methodological foundations of the complex application of risk assessment methods to prevent the adoption of its ...
L. V. Kuznetsova, A. N. Kuznietsov, Ju. B. Derkach   +2 more
doaj   +1 more source

Properties and functions of organic materials in poor agricultural soil condition [PDF]

, 2012
A field experiment was conducted under different soil strata in poor agricultural soil condition. Each soil stratum was treated separately with different organic material for soil fertility management.
Usman, Suleiman
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rational areas of using buses of different classes of passenger capacity [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2018
Problem. One of the key issues of the public transit operating is the choice of vehicles passenger capacity. This parameter has a wide range of var-iation and the basis arises for the segregation of buses into classes. The use of buses of a certain class
D. Ponkratov, N. Davidich
doaj   +1 more source

Modern Management Options for Ph plus ALL

, 2022
Simple Summary The use of tyrosine kinase inhibitors has represented a major step forward in the therapy of Philadelphia chromosome positive acute lymphoblastic leukemia. Recent improvements in the therapy are focused on early use of third generation tyrosine kinase inhibitors, their combination with immunotherapy, the refined indication of allogeneic ...
Ribera, JM, Chiaretti, S
openaire   +1 more source