Results 61 to 70 of about 4,524 (133)

Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Carbonic anhydrases (CAs) are ubiquitous metalloenzymes, which started to be investigated in detail in pathogenic, as well as non-pathogenic species since their pivotal role is to accelerate the physiological CO2 hydration/dehydration reaction ...
Alessandra Rogato, Sonia Del Prete, Alessio Nocentini, Vincenzo Carginale, Claudiu T. Supuran, Clemente Capasso   +5 more
doaj   +1 more source

Isolation and Characterization of the Diatom Phaeodactylum Δ5-Elongase Gene for Transgenic LC-PUFA Production in Pichia pastoris

Marine Drugs, 2014
The diatom Phaeodactylum tricornutum can accumulate eicosapentaenoic acid (EPA) up to 30% of the total fatty acids. This species has been targeted for isolating gene encoding desaturases and elongases for long-chain polyunsaturated fatty acid (LC-PUFA ...
Mulan Jiang, Bing Guo, Xia Wan, Yangmin Gong, Yinbo Zhang, Chuanjiong Hu   +5 more
doaj   +1 more source

Microalgae Cultivation: Nutrient Recovery from Digestate for Producing Algae Biomass

Chemical Engineering Transactions, 2015
The aim of this work was to compare the growth rate of algae in mineral medium and in ultrafiltrate medium. The ultrafiltrate allowed us to recover nutrients from a stream of digestate from agroindustrial sources.
D. Veronesi, A. Ida, G. D’Imporzano, F. Adani   +3 more
doaj   +1 more source

A model for carbohydrate metabolism in the diatom Phaeodactylum tricornutum deduced from comparative whole genome analysis.

PLoS ONE, 2008
BackgroundDiatoms are unicellular algae responsible for approximately 20% of global carbon fixation. Their evolution by secondary endocytobiosis resulted in a complex cellular structure and metabolism compared to algae with primary plastids.Methodology ...
Peter G Kroth, Anthony Chiovitti, Ansgar Gruber, Veronique Martin-Jezequel, Thomas Mock, Micaela Schnitzler Parker, Michele S Stanley, Aaron Kaplan, Lise Caron, Till Weber, Uma Maheswari, E Virginia Armbrust, Chris Bowler   +12 more
doaj   +1 more source

Iron Deficiency Induces a Partial Inhibition of the Photosynthetic Electron Transport and a High Sensitivity to Light in the Diatom Phaeodactylum tricornutum

Frontiers in Plant Science, 2016
Iron limitation is the major factor controlling phytoplankton growth in vast regions of the contemporary oceans. In this study, a combination of thermoluminescence, chlorophyll fluorescence and P700 absorbance measurements have been used to elucidate the
Mercedes Roncel, Antonio Alfonso González-Rodríguez, Belén Naranjo, Pilar Bernal-Bayard, Anna Marika Lindahl, Manuel Hervás, José Antonio Navarro, José María Ortega   +7 more
doaj   +1 more source

The Role of Malic Enzyme on Promoting Total Lipid and Fatty Acid Production in Phaeodactylum tricornutum

Frontiers in Plant Science, 2018
To verify the function of malic enzyme (ME1), the ME1 gene was endogenously overexpressed in Phaeodactylum tricornutum. Overexpression of ME1 increased neutral and total lipid content and significantly increased saturated fatty acids (SFAs) and ...
Bao-Hua Zhu, Rui-Hao Zhang, Na-Na Lv, Guan-Pin Yang, Yi-Sheng Wang, Ke-Hou Pan, Ke-Hou Pan   +6 more
doaj   +1 more source

Metabolic engineering of omega-3 long chain polyunsaturated fatty acids in plants using different ∆6- and ∆5-desaturases co-expressed with LPCAT from the marine diatom Phaeodactylum tricornutum

Scientific Reports
Continuous research on obtaining an even more efficient production of very long-chain polyunsaturated fatty acids (VLC-PUFAs) in plants remains one of the main challenges of scientists working on plant lipids.
Sylwia Klińska-Bąchor, Kamil Demski, Yangmin Gong, Antoni Banaś   +3 more
doaj   +1 more source

Meta-analysis of RNA-Seq datasets allows a better understanding of P. tricornutum cellular biology, a requirement to improve the production of Biologics

Scientific Reports
The marine diatom Phaeodactylum tricornutum is currently used for various industrial applications, including the pharmaceutical industry as a cost-effective cell biofactory to produce Biologics. Recent studies demonstrated that P. tricornutum can produce
Isabelle Boulogne, Charlotte Toustou, Muriel Bardor   +2 more
doaj   +1 more source

Comparative RNA-Seq of Ten Phaeodactylum tricornutum Accessions: Unravelling Criteria for Robust Strain Selection from a Bioproduction Point of View

Marine Drugs
The production of biologics in mammalian cells is hindered by some limitations including high production costs, prompting the exploration of other alternative expression systems that are cheaper and sustainable like microalgae.
Charlotte Toustou, Isabelle Boulogne, Anne-Alicia Gonzalez, Muriel Bardor   +3 more
doaj   +1 more source

Influence of harvesting method on biomass yield and antimicrobial activity of Isochrysis galbana and Phaeodactylum tricornutum extracts. [PDF]

Biotechnol Lett
Freitas de Siqueira Junior E, Fernandez LG, Rodrigues ED, da Cunha Lima ST.   +3 more
europepmc   +1 more source