Results 261 to 270 of about 469,268 (356)
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
Characterization, genomic analysis, and decontamination application of a novel Vibrio phage BUCT787 on salmon fillets. [PDF]
Xiao J, Dai H, Lv X, Li M, Li M, Tong Y.
europepmc +1 more source
The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna +4 more
wiley +1 more source
A phage cocktail with bactericidal and virulence-attenuating effects against dairy-associated hypervirulent <i>Klebsiella pneumoniae</i>. [PDF]
Ji X +6 more
europepmc +1 more source
Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli
Zhang, Kexin +13 more
openalex +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Capturing dynamic phage-pathogen coevolution by clinical surveillance. [PDF]
Mathur Y +8 more
europepmc +1 more source

