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Phage therapy

Nature Reviews Methods Primers
Bacteriophage (phages) are viruses that exclusively use bacterial cells for propagation, killing the bacterial host in the process. In phage therapy, phages are used to reduce bacterial numbers, thereby curing bacterial infections. Although this principle is conceptually straightforward, its practical application faces several hurdles.
Mikael Skurnik, Jean-Paul Pirnay, Saija Johanna Kiljunen   +2 more
exaly   +9 more sources

Phage Therapy

WikiJournal of Medicine, 2021
Phage therapy refers to the use of bacteriophages (phages - bacterial viruses) as therapeutic agents against infectious bacterial diseases. This therapeutic approach emerged in the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the second world war.
Joana Azeredo, Jean-Paul Pirnay, Diana P. Pires, Mzia Kutateladze, Krystyna Dabrowska, Rob Lavigne, Bob Blasdel   +6 more
openaire   +3 more sources

Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments

Frontiers in Pharmacology, 2021
Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Levan Pipia, Lia Nadareishvili, Dea Nizharadze   +5 more
doaj   +1 more source

Phage Therapy in Veterinary Medicine [PDF]

Antibiotics, 2021
To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects ...
Loponte R., Pagnini U., Iovane G., Pisanelli G.   +3 more
openaire   +5 more sources

Case report: Successful treatment of recurrent E. coli infection with bacteriophage therapy for patient suffering from chronic bacterial prostatitis

Frontiers in Pharmacology, 2023
Background: Chronic Bacterial Prostatitis (CBP) is inflammation of the prostate caused by bacterial infection. An estimated 8.2% of men have prostatitis, most commonly under the age of 50.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Naomi Hoyle, Lia Nadareishvili, Levan Pipia, Dea Nizharadze   +6 more
doaj   +1 more source

DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins

Frontiers in Microbiology, 2021
Introduction: Increasing number of deaths from multi-drug resistant bacterial infections has caused both the World Health Organization and the Centers for Disease Control and Prevention to repeatedly call for development of new, non-traditional ...
Marek Harhala, Marek Harhala, Katarzyna Gembara, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson, Krystyna Dąbrowska, Krystyna Dąbrowska   +11 more
doaj   +1 more source

Immunogenicity of Endolysin PlyC

Antibiotics, 2022
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms.
Marek Adam Harhala, Katarzyna Gembara, Daniel C. Nelson, Paulina Miernikiewicz, Krystyna Dąbrowska   +4 more
doaj   +1 more source

Isolation and characterisation of Klebsiella phages for phage therapy [PDF]

PHAGE: Therapy, Applications, and Research, 2020
Abstract Klebsiella is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection and sepsis. Bacteriophage (phage) therapy is being considered as a primary option for the treatment
Eleanor Townsend, Lucy Kelly, Lucy Gannon, George Muscatt, Rhys Dunstan, Slawomir Michniewski, Hari Sapkota, Saija J Kiljunen, Anna Kolsi, Mikael Skurnik, Trevor Lithgow, Andrew D. Millard, Eleanor Jameson   +12 more
openaire   +4 more sources

Two Newly Isolated Enterobacter-Specific Bacteriophages: Biological Properties and Stability Studies

Viruses, 2022
In an era of antibiotic therapy crisis caused by spreading antimicrobial resistance, and when recurrent urinary tract infections constitute a serious social and medical problem, the isolation and complex characterization of phages with a potential ...
Martyna Cieślik, Marek Harhala, Filip Orwat, Krystyna Dąbrowska, Andrzej Górski, Ewa Jończyk-Matysiak   +5 more
doaj   +1 more source

New formula of the green synthesised Au@Ag core@shell nanoparticles using propolis extract presented high antibacterial and anticancer activity

AMB Express, 2022
Antimicrobial alternatives such as nanoparticles are critically required to tackle bacterial infections, especially with the emerging threat of antibiotic resistance.
Nouran Rezk, Abdallah S. Abdelsattar, Salsabil Makky, Assmaa H. Hussein, Azza G. Kamel, Ayman El-Shibiny   +5 more
doaj   +1 more source