Results 41 to 50 of about 72,592 (256)

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Large-genome phage vB_Eco_ZCEC15 targets gastrointestinal MDR E. coli: evidence from in vitro and Caco-2 cell models

BMC Microbiology
Background Bacterial resistance to traditional antibiotics is spreading at an alarming rate, threatening public health and various industrial applications.
Kareem Essam, Amira A. Mohamed, Salsabil Makky, Azza G. Kamel, Ayman El-Shibiny   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Green synthesis of silver and gold-doped zinc oxide nanocomposite with propolis extract for enhanced anticancer activity

Scientific Reports
Metal and metal oxide nanocomposites have unique properties and are promising for antibacterial and anticancer applications. In this work, we aimed to highlight the relationship between the biosynthesis ways of silver and gold-doped zinc oxide ...
Abdallah S. Abdelsattar, Aghapy Yermans Yakoup, Azza G. Kamel, Ayman El-Shibiny   +3 more
doaj   +1 more source

Bacteriophage-based nano-biosensors for the fast impedimetric determination of pathogens in food samples

Scientific Reports, 2023
The early and rapid detection of pathogenic microorganisms is of critical importance in addressing serious public health issues. Here, a new bacteriophage-based nano-biosensor was constructed and the electrochemical impedimetric method was fully ...
Nader Abdelhamied, Fatma Abdelrahman, Ayman El-Shibiny, Rabeay Y. A. Hassan   +3 more
doaj   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Extensive library of Ruminococcus gnavus phages revealing genomic and phenotypic diversity with novel clusters

Microbiology Spectrum
Ruminococcus gnavus is a prevalent member of human gut microbiota and is associated with inflammatory bowel disease. Phage-based microbiota engineering represents a promising approach for alleviating dysbiosis; however, knowledge regarding R.
Arata Sakiyama, Ayaka Washizaki, Keiko Inaba-Hasegawa, Most Hushna Ara Naznin, Keigo Ide, Masayuki Takase, Yoriko Ibuki, Yuichi Sawaguchi, Shoichi Mitsunaka, Yutaro Ono, Islam Mohammad Shyful, Hiroki Ando   +11 more
doaj   +1 more source

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

EMBO Molecular Medicine, 2019
Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced
Justyna Magdalena Przystal, Sajee Waramit, Md Zahidul Islam Pranjol, Wenqing Yan, Grace Chu, Aitthiphon Chongchai, Gargi Samarth, Nagore Gene Olaciregui, Ghazaleh Tabatabai, Angel Montero Carcaboso, Eric Ofori Aboagye, Keittisak Suwan, Amin Hajitou   +12 more
doaj   +1 more source