Results 41 to 50 of about 2,471,270 (185)

Encapsulation of E. coli phage ZCEC5 in chitosan–alginate beads as a delivery system in phage therapy

AMB Express, 2019
Bacteriophages can be used successfully to treat pathogenic bacteria in the food chain including zoonotic pathogens that colonize the intestines of farm animals.
Abdallah S. Abdelsattar, Fatma Abdelrahman, Alyaa Dawoud, Ian F. Connerton, Ayman El-Shibiny   +4 more
doaj   +1 more source

Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses

Frontiers in Immunology, 2023
Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino
Marek Adam Harhala, Marek Adam Harhala, Katarzyna Gembara, Katarzyna Gembara, Izabela Rybicka, Zuzanna Maria Kaźmierczak, Zuzanna Maria Kaźmierczak, Paulina Miernikiewicz, Joanna Marta Majewska, Wiktoria Budziar, Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska, Krystyna Dąbrowska   +14 more
doaj   +1 more source

Phage therapy against Pseudomonas aeruginosa infections in cystic fibrosis patients

, 2016
Pseudomonas aeruginosa is the most common pathogen found in the lung of cystic fibrosis patients. The use of phage therapy could help in fighting the alarming diffusion of antibiotic multi-resistant strains.
F. Briani, D. Ghisotti, F. Forti
core   +2 more sources

How to Train Your Phage: The Recent Efforts in Phage Training

Biologics, 2021
Control of pathogenic bacteria by deliberate application of predatory phages has potential as a powerful therapy against antibiotic-resistant bacteria.
Abdallah S. Abdelsattar, Alyaa Dawooud, Nouran Rezk, Salsabil Makky, Anan Safwat, Philip J. Richards, Ayman El-Shibiny   +6 more
doaj   +1 more source

The bacteriophage decides own tracks: When they are with or against the bacteria

Current Research in Microbial Sciences, 2021
Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial ...
Salsabil Makky, Alyaa Dawoud, Anan Safwat, Abdallah S. Abdelsattar, Nouran Rezk, Ayman El-Shibiny   +5 more
doaj   +1 more source

Isolation, Characterization, and Genomic Analysis of Three Novel E. coli Bacteriophages That Effectively Infect E. coli O18

Microorganisms, 2022
Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to the poultry industry and public health
Fatma Abdelrahman, Nouran Rezk, Mohamed S. Fayez, Mohamed Abdelmoteleb, Reham Atteya, Mohamed Elhadidy, Ayman El-Shibiny   +6 more
doaj   +1 more source

Identification of Cohesive Ends and Genes Encoding the Terminase of Phage 16-3 [PDF]

, 2005
Cohesive ends of 16-3, a temperate phage of Rhizobium meliloti 41, have been identified as 10-base-long, 3′-protruding complementary G/C-rich sequences. terS and terL encode the two subunits of 16-3 terminase.
Papp, P. P., Ponyi, T., Buzas, Z., Ganyu, A., Orosz, László, Csiszovszki, Z., Kern, A.   +6 more
core   +1 more source

Addressing the research and development gaps in modern phage therapy [PDF]

Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major
Turner, Paul, Moreno, Mercedes Gonzalez, Azeredo, Joana, Haaber, Jakob Krause, Portillo, Mirza Alas, Green, Sabrina, Kameda de Figueiredo Carvalho, Koichi, Haggstrom, Douglas, Kirchhelle, Claas, Carvalho, Koichi Kameda de Figueiredo, Pirnay, Jean-Paul, Gonzalez Moreno, Mercedes, Buurman, Ed. T., Buurman, Ed, Turner, Paul E.   +14 more
core   +1 more source

Phage Neutralization by Sera of Patients Receiving Phage Therapy [PDF]

Viral Immunology, 2014
The aim of our investigation was to verify whether phage therapy (PT) can induce antiphage antibodies. The antiphage activity was determined in sera from 122 patients from the Phage Therapy Unit in Wrocław with bacterial infections before and during PT, and in sera from 30 healthy volunteers using a neutralization test. Furthermore, levels of antiphage
Łusiak-Szelachowska, Marzanna, Żaczek, Maciej, Weber-Dąbrowska, Beata, Ryszard Andrzej Międzybrodzki, Kłak, Marlena, Wojciech Fortuna, Letkiewicz, Sławomir, Rogóż, Paweł, Szufnarowski, Krzysztof, Jończyk-Matysiak, Ewa, Owczarek, Barbara, Andrzej Górski   +11 more
openaire   +3 more sources

Characterization, antibacterial, and cytotoxic activities of silver nanoparticles using the whole biofilm layer as a macromolecule in biosynthesis

Scientific Reports
Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue.
Aghapy Yermans Yakoup, Azza G. Kamel, Yasmin Elbermawy, Abdallah S. Abdelsattar, Ayman El-Shibiny   +4 more
doaj   +1 more source