Results 51 to 60 of about 2,642,573 (281)

How Phage Therapy Works, Its Advantages and Disadvantages: Mini Review [PDF]

Phage therapy is a treatment method that uses bacteriophages, which are viruses that infect bacteria, to treat bacterial infections. Phages are natural adversaries, helping to restrict their proliferation in the natural environment. Phages are made up of
Sarita Ugemuge, Nandkishor Bankar, Vaishnavi Mishra, Yugeshwari Tiwade   +3 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Isolation, Characterization, and Genomic Analysis of Three Novel E. coli Bacteriophages That Effectively Infect E. coli O18

Microorganisms, 2022
Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to the poultry industry and public health
Fatma Abdelrahman, Nouran Rezk, Mohamed S. Fayez, Mohamed Abdelmoteleb, Reham Atteya, Mohamed Elhadidy, Ayman El-Shibiny   +6 more
doaj   +1 more source

Overcoming Bacteriophage Resistance in Phage Therapy

, 2023
Antibiotic resistance among pathogenic bacteria is one of the most severe global challenges. It is predicted that over ten million lives will be lost annually by 2050. Phage therapy is a promising alternative to antibiotics.
Laanto, Elina
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Phage Neutralization by Sera of Patients Receiving Phage Therapy [PDF]

Viral Immunology, 2014
The aim of our investigation was to verify whether phage therapy (PT) can induce antiphage antibodies. The antiphage activity was determined in sera from 122 patients from the Phage Therapy Unit in Wrocław with bacterial infections before and during PT, and in sera from 30 healthy volunteers using a neutralization test. Furthermore, levels of antiphage
Łusiak-Szelachowska, Marzanna, Żaczek, Maciej, Weber-Dąbrowska, Beata, Ryszard Andrzej Międzybrodzki, Kłak, Marlena, Wojciech Fortuna, Letkiewicz, Sławomir, Rogóż, Paweł, Szufnarowski, Krzysztof, Jończyk-Matysiak, Ewa, Owczarek, Barbara, Andrzej Górski   +11 more
openaire   +3 more sources

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Characterization, antibacterial, and cytotoxic activities of silver nanoparticles using the whole biofilm layer as a macromolecule in biosynthesis

Scientific Reports
Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue.
Aghapy Yermans Yakoup, Azza G. Kamel, Yasmin Elbermawy, Abdallah S. Abdelsattar, Ayman El-Shibiny   +4 more
doaj   +1 more source

Addressing the Research and Development Gaps in Modern Phage Therapy [PDF]

Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major
Turner, Paul, Moreno, Mercedes Gonzalez, Azeredo, Joana, Haaber, Jakob Krause, Portillo, Mirza Alas, Green, Sabrina, Kameda de Figueiredo Carvalho, Koichi, Haggstrom, Douglas, Kirchhelle, Claas, Carvalho, Koichi Kameda de Figueiredo, Pirnay, Jean-Paul, Gonzalez Moreno, Mercedes, Buurman, Ed. T., Buurman, Ed, Turner, Paul E., Kameda, Koichi, Buurman, Ed T.   +16 more
core   +1 more source