Results 281 to 290 of about 531,900 (348)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Large-scale analysis of bacterial genomes reveals thousands of lytic phages. [PDF]

open access: yesNat Microbiol
Perfilyev A   +18 more
europepmc   +1 more source

Phage PM16 Therapy Induce Long-Term Protective Immunity Against Proteus mirabilis via Macrophage Priming. [PDF]

open access: yesPathogens
Al Allaf L   +5 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy