Results 151 to 160 of about 4,514,314 (397)

From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy

Advanced Science, EarlyView.
This review explores how multi‐omics, visualization technologies, and AI drive CAR‐T therapy from the micro to the macro level, from preclinical studies to clinical applications. The convergence of these approaches provides deeper insight into CAR‐T cell mechanisms, aids in structural optimization, and significantly enhances treatment efficacy and ...
Yuting Gong, Peng Fei, Yicheng Zhang, Yang Xu, Jia Wei   +4 more
wiley   +1 more source

Bacterial competition and quorum-sensing signalling shapes the eco-evolutionary outcomes of model in vitro phage therapy [PDF]

, 2016
The rapid rise of antibiotic resistance has renewed interest in phage therapy - the use of bacteria-specific viruses (phages) to treat bacterial infections.
Abedon, Alisky, Andersen, Asfahl, Betts, Betts, Buckling, Debarbieux, Diggle, Essoh, Expert round table on, acceptance and therapy re-implementation of bacteriophage, Fletcher, Folkesson, Friman, Friman, Friman, Frydenlund Michelsen, Ghoul, Glessner, Hall, Harcombe, Harper, Harrison, Harrison, Hoffman, Housby, Hoyland-Kroghsbo, Inglis, Jelsbak, Jorth, Kassen, Korgaonkar, Kutateladze, Lenski, Levin, Levy, Lopez-Pascua, Marvig, Merabishvili, Merabishvili, Michelsen, Miller, Peters, R Core Team, Rose, Rossolini, Ryan, Seed, Smith, Strateva, Taj, Tan, Turner, Vasse, Yoshida   +54 more
core   +2 more sources

Synergy as a rationale for phage therapy using phage cocktails

PeerJ, 2014
Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any single phage (synergy) or the combination may be worse than the best single phage (interference ...
James J. Bull, Ian J. Molineux, Matthew Schmerer   +2 more
openaire   +3 more sources

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

The bacteriophage decides own tracks: When they are with or against the bacteria

Current Research in Microbial Sciences, 2021
Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial ...
Salsabil Makky, Alyaa Dawoud, Anan Safwat, Abdallah S. Abdelsattar, Nouran Rezk, Ayman El-Shibiny   +5 more
doaj  

Isolation and Characterization of Phage Specific to E. Coli O157:H7 [PDF]

, 2012
. Phage therapy is not new because it has been practiced since the early 1900s to cure diseases such as shigellosis, typhus and dysentery that caused by bacteria.
Arip, Y. M. (Yahya), Zaman, S. F. (Siti)
core  

Bacteriophages and their structural organisation [PDF]

, 2012
Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
Orlova, Elena
core   +2 more sources

A Unique THN Motif Is Critical for Enabling Efficient C‐Terminal Traceless Cleavage

Advanced Science, EarlyView.
THN is identified as the key motif to facilitate the rapid traceless cleavage of gp41‐1. The deflection of THN motif not only avoids the interaction between C‐exteins and active sites, but also separates Asp107 away from Asn125. In addition, a flexible block F contributes to faster C‐cleavage.
Ruocheng Gu, Yunuo Lin, Rouyu Di, Tongtong Zhou, Tingwen Fan, Wei Li, Lili Miao, Huaiyi Yang   +7 more
wiley   +1 more source

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University

Scientific Reports
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d’Hérelle’s first publication on the clinical applications of phages.
Silvia Würstle, Alina Lee, Kaitlyn E. Kortright, Franziska Winzig, William An, Gail L. Stanley, Govindarajan Rajagopalan, Zach Harris, Ying Sun, Buqu Hu, Michael Blazanin, Maryam Hajfathalian, Paul L. Bollyky, Paul E. Turner, Jonathan L. Koff, Benjamin K. Chan   +15 more
doaj   +1 more source

Mathematical Modeling of CRISPR-CAS system effects on biofilm formation [PDF]

arXiv, 2016
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), linked with CRISPR associated (CAS) genes, play a profound role in the interactions between phage and their bacterial hosts. It is now well understood that CRISPR-CAS systems can confer adaptive immunity against bacteriophage infections.
arxiv