Results 251 to 260 of about 114,190 (344)

Phage therapy for Klebsiella pneumoniae: Understanding bacteria-phage interactions for therapeutic innovations. [PDF]

PLoS Pathog
Le Bris J, Chen N, Supandy A, Rendueles O, Van Tyne D.   +4 more
europepmc   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy. [PDF]

Nat Commun
Zborowsky S, Seurat J, Balacheff Q, Ecomard S, Mulet C, Minh CNN, Titécat M, Evrard E, Rodriguez-Gonzalez RA, Marchi J, Weitz JS, Debarbieux L.   +11 more
europepmc   +1 more source

Novel nanoparticle‐mediated plasmid delivery in bacteria for difficult applications

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 1, Page 123-134, January 2026.
Abstract BACKGROUND This study presents the development and application of magnetite/silver‐pDMAEMA‐PEG‐BUFII nanobioconjugates as an advanced plasmid delivery system in bacteria. These nanobioconjugates demonstrated superior efficiency compared to traditional methods in four challenging applications: (i) genomic editing in Gram‐positive bacteria; (ii)
Laura D. Páez‐Angarita, Laura X. Henao, Sebastián Jaramillo‐Toro, Valentina Quezada, Silvia Restrepo, Juan C. Cruz, Johana Husserl   +6 more
wiley   +1 more source

Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States. [PDF]

Antibiotics (Basel)
Kline A, Cobián Güemes AG, Yore J, Ghose C, Van Tyne D, Whiteson K, Pride DT.   +6 more
europepmc   +1 more source

Mycobacteriophage Mcgavigan Uses Noncanonical Bxb1‐Like Repressor for Heterotypic Superinfection Immunity

Journal of Basic Microbiology, Volume 66, Issue 1, January 2026.
ABSTRACT Mycobacteriophage Mcgavigan could be a promising candidate for use as a preventative agent against infections with Mycobacterium avium subsp. paratuberculosis. Bioinformatic analysis of the Mcgavigan genome revealed the presence of an operon containing a “Bxb1‐like” repressor.
Natali Shafer, Bradley E. Dubrule, Jeroen De Buck   +2 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Ethical argument for establishing good manufacturing practice for phage therapy in the UK. [PDF]

J Med Ethics
Suleman M, Clark JR, Bull S, Jones JD.
europepmc   +1 more source

Expanding the Genetic and Phenotypic Spectrum of POLRMT‐Related Mitochondrial Disease

Clinical Genetics, Volume 109, Issue 1, Page 167-175, January 2026.
We identified potentially damaging monoallelic and biallelic POLRMT variants in affected individuals from six unrelated families, thus extending both the clinical and genetic phenotypes of POLRMT‐related mitochondrial disease. ABSTRACT Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity ...
Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V. Y. Knowles, Eleni Mavraki, Miriam Elbracht, Nergis Güzel, Thomas Herberhold, Ingo Kurth, Andrea Maier, Larissa Mattern, Carol Saunders, Helen McCullagh, Katrin Õunap, Saskia B. Wortmann, Andre Reis, Lei Zhang, Claes M. Gustafsson, Robert McFarland, Robert W. Taylor   +20 more
wiley   +1 more source

Phage-specific antibodies: are they a hurdle for the success of phage therapy? [PDF]

Essays Biochem
Washizaki A, Sakiyama A, Ando H.
europepmc   +1 more source