Results 261 to 270 of about 4,525,509 (335)

Phage therapy in the management of respiratory and pulmonary infections: a systematic review. [PDF]

Ther Adv Infect Dis
Sarkodie-Addo P, Osman AH, Aglomasa BC, Donkor ES.   +3 more
europepmc   +1 more source

Isolation and Genomic Analysis of <i>Escherichia coli</i> Phage AUBRB02: Implications for Phage Therapy in Lebanon. [PDF]

Antibiotics (Basel)
Abdo Ahmad TA, El Houjeiry SA, Abou Fayad A, Kanj SS, Matar GM, Saba ES.   +5 more
europepmc   +1 more source

Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Proteolytic balance is dysregulated in many diseases, with proteases playing critical roles in pathological pathways. A high level of Trypsin‐3 expression has been implicated as a significant mediator of tumour progression and metastasis, and this protease is associated with poor prognosis for patients in various cancers.
Melissa David, Anaïs Faihy, Corinne Rolland, Anissa Edir, Astrid Canivet, Laetitia Ligat, Mireille Sebbag, Nathalie Vergnolle, Aurélien Olichon, Céline Deraison   +9 more
wiley   +1 more source

Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial. [PDF]

Nat Commun
Weiner I, Kahan-Hanum M, Buchstab N, Zelcbuch L, Navok S, Sherman I, Nicenboim J, Axelrod T, Berko-Ashur D, Olshina M, Mordoch R, Jablonska J, Gera-Inbar T, Vainberg-Slutskin I, Blumenfeld B, Sberro-Livnat H, Moses A, Nevenzel H, Levy-Saar I, Gold J, Goldberg M, Tchernorudsky N, Ben-Yishay N, Cohen T, Kario E, Levovich I, Safonov R, Tzur Y, Zarchin Y, Lev V, Elharar Y, Safyon-Gartman E, Gahali-Sass I, Puttagunta S, Ussery X, Vilchez R, Rappo U, Zak N, Golembo M, Cohen A, Koff J, Kerem E, Sorek R, Bassan M.   +43 more
europepmc   +1 more source

Expanding the Genetic and Phenotypic Spectrum of POLRMT‐Related Mitochondrial Disease

Clinical Genetics, EarlyView.
We identified potentially damaging monoallelic and biallelic POLRMT variants in affected individuals from six unrelated families, thus extending both the clinical and genetic phenotypes of POLRMT‐related mitochondrial disease. ABSTRACT Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity ...
Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V. Y. Knowles, Eleni Mavraki, Miriam Elbracht, Nergis Güzel, Thomas Herberhold, Ingo Kurth, Andrea Maier, Larissa Mattern, Carol Saunders, Helen McCullagh, Katrin Õunap, Saskia B. Wortmann, Andre Reis, Lei Zhang, Claes M. Gustafsson, Robert McFarland, Robert W. Taylor   +20 more
wiley   +1 more source

Unveiling Prophage Diversity and Host Interactions in Liberibacter: Genomic Insights for Phage Therapy Against Citrus Huanglongbing. [PDF]

Biology (Basel)
Yin H, Wan J, Zhang S, Wu Z, Zhang W, Gao Y.   +5 more
europepmc   +1 more source

Phage Therapy in the Twenty-First Century: Facing the Decline of the Antibiotic Era; Is It Finally Time for the Age of the Phage?

, 2019
Shayla Hesse, Sankar Adhya
openalex   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

<p>Mechanistic research holds promise for bacterial vaccines and phage therapies for <em>Pseudomonas aeruginosa</em></p>

, 2019
Austin Hoggarth, Andrew Weaver, Qinqin Pu, Ting Huang, Jacob Schettler, Feng Chen, Xiefang Yuan, Min Wu   +7 more
openalex   +2 more sources