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2023
Cancer is currently a global health challenge, characterized by dysfunction of organs due to the uncontrolled growth of cells exponentially. The therapies used to treat cancer in patients so far are widely used. However, there are also some problems, such as the high cost of surgery and chemotherapy.
Hue Vu, Thi +3 more
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Cancer is currently a global health challenge, characterized by dysfunction of organs due to the uncontrolled growth of cells exponentially. The therapies used to treat cancer in patients so far are widely used. However, there are also some problems, such as the high cost of surgery and chemotherapy.
Hue Vu, Thi +3 more
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Drug Discovery Today, 2009
There is a renaissance of interest in the antimicrobial potential of phages as more pathogens become multiply antibiotic resistant. Phage therapy is not a new concept, and it is important to ask why it is not part of the current repertoire of western medicine despite the fact that it has been continuously and extensively used in Eastern Europe for ...
John N, Housby, Nicholas H, Mann
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There is a renaissance of interest in the antimicrobial potential of phages as more pathogens become multiply antibiotic resistant. Phage therapy is not a new concept, and it is important to ask why it is not part of the current repertoire of western medicine despite the fact that it has been continuously and extensively used in Eastern Europe for ...
John N, Housby, Nicholas H, Mann
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Current Pharmaceutical Biotechnology, 2010
Phage therapy--application of bacteria-specific viruses to reduce densities of pathogenic or nuisance bacteria--is a two-step process involving phage penetration to target bacteria followed by bacteria killing. Any analysis of these steps is inherently ecological as they represent phage-environment interactions, i.e., between phages and bacteria as ...
Stephen T, Abedon +1 more
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Phage therapy--application of bacteria-specific viruses to reduce densities of pathogenic or nuisance bacteria--is a two-step process involving phage penetration to target bacteria followed by bacteria killing. Any analysis of these steps is inherently ecological as they represent phage-environment interactions, i.e., between phages and bacteria as ...
Stephen T, Abedon +1 more
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Reviews in Medical Virology, 2019
SummaryBacteriophages or phages, being the most abundant entities on earth, represent a potential solution to a diverse range of problems. Phages are successful antibacterial agents whose use in therapeutics was hindered by the discovery of antibiotics.
Sana Rehman +4 more
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SummaryBacteriophages or phages, being the most abundant entities on earth, represent a potential solution to a diverse range of problems. Phages are successful antibacterial agents whose use in therapeutics was hindered by the discovery of antibiotics.
Sana Rehman +4 more
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Synthetic phage and its application in phage therapy
2023Synthetic phage analysis has been implemented in progressive various areas of biology, such as genetics, molecular biology, and synthetic biology. Many phage-derived technologies have been altered for developing gene circuits to program biological systems.
Ajay, Kumar, Anuj, Yadav
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2005
Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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Phage Choice, Isolation, and Preparation for Phage Therapy
Current Pharmaceutical Biotechnology, 2010Phage therapy is the use of bacteriophages--viruses that use bacteria as their host cells--as biocontrol agents of bacteria. Currently, phage therapy is garnering renewed interest as bacterial resistance to antibiotics becomes widespread. Historically, phage therapy was largely abandoned in the West in the 1940s due to the advent of chemical ...
Jason J, Gill, Paul, Hyman
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Models of phage growth and their applicability to phage therapy
Journal of Theoretical Biology, 2004Phage therapy is complicated by the self-replicating nature of phage. It is difficult to extrapolate from in vitro phage growth data to in vivo expectations, difficult to interpret in vivo data and difficult to generalize from one in vivo situation to another.
Richard J, Weld +2 more
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Phage Vaccines and Phage Therapy
2011The application of combinatorial approaches in conjunction with phage display techniques might be critical for development of vaccines against various infective and cancer diseases. Phage technique allows the generation of novel immunogens representing structural/molecular mimics of pathogen-derived immunodominant epitopes, or protein domains displayed
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