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Current Pharmaceutical Biotechnology, 2010
Phage therapy--application of bacteria-specific viruses to reduce densities of pathogenic or nuisance bacteria--is a two-step process involving phage penetration to target bacteria followed by bacteria killing. Any analysis of these steps is inherently ecological as they represent phage-environment interactions, i.e., between phages and bacteria as ...
Stephen T, Abedon +1 more
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Phage therapy--application of bacteria-specific viruses to reduce densities of pathogenic or nuisance bacteria--is a two-step process involving phage penetration to target bacteria followed by bacteria killing. Any analysis of these steps is inherently ecological as they represent phage-environment interactions, i.e., between phages and bacteria as ...
Stephen T, Abedon +1 more
openaire +2 more sources
2005
Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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Abstract The ability of bacteriophage (phage) to replicate exponentially and lyse pathogenic strains of bacteria suggests that they should play a vital role in our armamentarium for the treatment of infectious diseases. However, in spite of an initial enthusiasm, early clinical applications resulted in a negative shift of opinion ...
Carl R Merril, Dean Scholl, Sankar Adhya
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2023
Cancer is currently a global health challenge, characterized by dysfunction of organs due to the uncontrolled growth of cells exponentially. The therapies used to treat cancer in patients so far are widely used. However, there are also some problems, such as the high cost of surgery and chemotherapy.
Hue Vu, Thi +3 more
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Cancer is currently a global health challenge, characterized by dysfunction of organs due to the uncontrolled growth of cells exponentially. The therapies used to treat cancer in patients so far are widely used. However, there are also some problems, such as the high cost of surgery and chemotherapy.
Hue Vu, Thi +3 more
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Phage Therapy: Future Inquiries
Postdoc Journal, 2013Western scientists have steadily been gaining interest in phage therapy since the mid-1980's due to the rising problem of antibiotic resistance. Its introduction in the 20th century by Felix d'Herelle marked the beginning for the uses of bacteriophages as antibacterial agents.
Sijia, Wu +3 more
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Synthetic phage and its application in phage therapy
2023Synthetic phage analysis has been implemented in progressive various areas of biology, such as genetics, molecular biology, and synthetic biology. Many phage-derived technologies have been altered for developing gene circuits to program biological systems.
Ajay, Kumar, Anuj, Yadav
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Phage Choice, Isolation, and Preparation for Phage Therapy
Current Pharmaceutical Biotechnology, 2010Phage therapy is the use of bacteriophages--viruses that use bacteria as their host cells--as biocontrol agents of bacteria. Currently, phage therapy is garnering renewed interest as bacterial resistance to antibiotics becomes widespread. Historically, phage therapy was largely abandoned in the West in the 1940s due to the advent of chemical ...
Jason J, Gill, Paul, Hyman
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Current Gene Therapy, 2017
Bacteriophages (bacterial viruses) have long been under investigation as vectors for gene therapy. Similar to other viral vectors, the phage coat proteins have evolved over millions of years to protect the viral genome from degradation post injection, offering protection for the valuable therapeutic sequence.However, what sets phage apart from other ...
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Bacteriophages (bacterial viruses) have long been under investigation as vectors for gene therapy. Similar to other viral vectors, the phage coat proteins have evolved over millions of years to protect the viral genome from degradation post injection, offering protection for the valuable therapeutic sequence.However, what sets phage apart from other ...
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Phage Vaccines and Phage Therapy
2011The application of combinatorial approaches in conjunction with phage display techniques might be critical for development of vaccines against various infective and cancer diseases. Phage technique allows the generation of novel immunogens representing structural/molecular mimics of pathogen-derived immunodominant epitopes, or protein domains displayed
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Phage therapy pharmacology phage cocktails.
Advances in applied microbiology, 2016Phage therapy is the clinical or veterinary application of bacterial viruses (bacteriophages) as antibacterial "drugs." More generally, phages can be used as biocontrol agents against plant as well as foodborne pathogens. In this chapter, we consider the therapeutic use of phage cocktails, which is the combining of two or more phage types to produce ...
Benjamin K, Chan, Stephen T, Abedon
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