Results 51 to 60 of about 33,934 (266)

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes

mBio
Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. The bacteria replicate in epithelial cells from which they take up sphingolipids (SL) and incorporate them into the chlamydial ...
Adriana Moldovan, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, David Komla Kessie, Marcel Rühling, Kathrin Stelzner, Regina Tschertok, Louise Kersting, Julian Fink, Jürgen Seibel, Burkhard Kleuser, Thomas Rudel   +12 more
doaj   +1 more source

Wearable OLED‐Assisted Photodynamic Cancer Therapy Using Chlorin e6‐Loaded Pluronic Nanocapsules as Photosensitizers

Advanced Healthcare Materials, EarlyView.
A novel photodynamic therapeutic approach has been employed for anticancer therapy, utilizing chlorin e6‐loaded Pluronic nanocapsules and a wearable organic light‐emitting diode light source. This has shown significant in vivo antitumor efficacy with minimal off‐target toxicity. The innovative combination of a wearable light source and photosensitizers
Hyeryeon Oh, Seung Min Jeong, Cheol Hui Park, Panmo Son, Yeseo Lee, Heebeom Koo, Won Il Choi, Kyung Cheol Choi   +7 more
wiley   +1 more source

Formation of Multinucleated Giant Cells after Experimental Intracerebral Hemorrhage: Characteristics and Role of Complement C3

Biomedicines
Hematoma clearance is critical for mitigating intracerebral hemorrhage (ICH)-induced brain injury. Multinucleated giant cells (MGCs), a type of phagocyte, and the complement system may play a pivotal role in hematoma resolution, but whether the ...
Xiongjie Fu, Ming Wang, Yingfeng Wan, Ya Hua, Richard F. Keep, Guohua Xi   +5 more
doaj   +1 more source

Immune status of patients with acne and concomitant skin malasseziosis

Patologìâ, 2013
Introduction: Acne is the most common skin disease that affects up to 85% of people between 12 and 25 years old and 11% of persons over the age of 25 years.
E. Yu. Koretskaya
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Development of an immunodeficient mouse that allows for conditional ablation of monocytic cells

Frontiers in Immunology
Background and aimsImmunodeficient mice, like the NOD-SCID-Gamma (NSG) strain, are important for the study of xenogeneic cells because of their lack of lymphocytes, dysfunctional hemolytic complement factor 5 (C5), and macrophage defects making them ...
Alvin J. Hui, Kelly Lai, Eva H. Doyle, Guadalupe Rivera-Torruco, Alan G. Gutierrez, Emily J. Du, Yarah B. M. Meijer, Gabrielle Smith, Renata Gilfanova, Kenton G. Chung, Kirsten M. Auclair, Pamela Milani, Pamela Milani, Rachael P. Jackman, Rachael P. Jackman, Johnson Q. Tran, Johnson Q. Tran, Marcus O. Muench, Marcus O. Muench   +18 more
doaj   +1 more source

The Origins and Functions of Tissue-Resident Macrophages in Kidney Development

Frontiers in Physiology, 2017
The adult kidney hosts tissue-resident macrophages that can cause, prevent, and/or repair renal damage. Most of these macrophages derive from embryonic progenitors that colonize the kidney during its development and proliferate in situ throughout ...
David A. D. Munro, Jeremy Hughes
doaj   +1 more source

Phagocyte activity reflects mammalian homeo- and hetero-thermic physiological states

BMC Veterinary Research, 2020
Background Emergence of both viral zoonoses from bats and diseases that threaten bat populations has highlighted the necessity for greater insights into the functioning of the bat immune system.
Jiri Pikula, Tomas Heger, Hana Bandouchova, Veronika Kovacova, Monika Nemcova, Ivana Papezikova, Vladimir Piacek, Renata Zajíčková, Jan Zukal   +8 more
doaj   +1 more source