Results 101 to 110 of about 248,663 (166)

Phagocytosis checkpoints as new targets for cancer immunotherapy

Nature Reviews. Cancer, 2019
Mingye Feng, Wen Jiang, Betty Y. S. Kim, C. Zhang, yang-xin fu, I. Weissman   +5 more
semanticscholar   +1 more source

Dimeric Drug Polymeric Micelles with Acid-Active Tumor Targeting and FRET-indicated Drug Release [PDF]

arXiv
Trans-activating transcriptional activator (TAT), a cell-penetrating peptide, has been extensively used for facilitating cellular uptake and nuclear targeting of drug delivery systems. However, the positively charged TAT peptide usually strongly interacts with serum components and undergoes substantial phagocytosis by the reticuloendothelial system ...
arxiv  

Tumor-associated CD19$^+$ macrophages induce immunosuppressive microenvironment in hepatocellular carcinoma [PDF]

arXiv
Tumor-associated macrophages are a key component that contributes to the immunosuppressive microenvironment in human cancers. However, therapeutic targeting of macrophages has been a challenge in clinic due to the limited understanding of their heterogeneous subpopulations and distinct functions. Here, we identify a unique and clinically relevant CD19$^
arxiv  

From Radiation Dose to Cellular Dynamics: A Discrete Model for Simulating Cancer Therapy [PDF]

arXiv
Radiation therapy is one of the most common cancer treatments, and dose optimization and targeting of radiation are crucial since both cancerous and healthy cells are affected. Different mathematical and computational approaches have been developed for this task.
arxiv  

Fat Phagocytosis Promotes Anti-Inflammatory Responses of Macrophages in a Mouse Model of Osteonecrosis

Cells
Osteonecrosis (ON) of the femoral head (ONFH) is a devastating bone disease affecting over 20 million people worldwide. ONFH is caused by a disruption of the blood supply, leading to necrotic cell death and increased inflammation. Macrophages are the key
Zhuo Deng, Harry K. W. Kim, Paula A. Hernandez, Yinshi Ren   +3 more
doaj   +1 more source

Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis

Journal of Neuroinflammation
Alzheimer’s disease (AD) is the leading form of dementia, characterized by the accumulation and aggregation of amyloid in brain. Transient receptor potential vanilloid 2 (TRPV2) is an ion channel involved in diverse physiopathological processes ...
Shaobin Yang, Yaqin Du, Yanhong Li, Qi Tang, Yimeng Zhang, Xiaoqian Zhao   +5 more
doaj   +1 more source

Phagocytosis: An Immunobiologic Process.

Immunity, 2016
S. Gordon
semanticscholar   +1 more source

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

Nature Cell Biology, 2015
Jennifer Martinez, R. Malireddi, Q. Lu, L. D. Cunha, S. Pelletier, S. Gingras, R. Orchard, J. Guan, H. Tan, Junmin Peng, T. Kanneganti, H. Virgin, D. Green   +12 more
semanticscholar   +1 more source

Brain endothelial cells as phagocytes: mechanisms and implications. [PDF]

Fluids Barriers CNS
Chang RT, Fisher MJ, Sumbria RK.
europepmc   +1 more source

Surface N- or O-linked glycans on bovine spermatozoa play minimal role in evading macrophage mediated phagocytosis. [PDF]

Front Vet Sci
Chera JS, Gaur V, Kumar A, Josan F, Patel A, Yadav S, Karanwal S, Verma P, Verma V, Kumar S, Bairagi AK, Kamal S, Datta TK, Kumar R.   +13 more
europepmc   +1 more source