Results 111 to 120 of about 420,323 (395)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]

, 2015
Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall, AK Neumann, B Amulic, B Enjalbert, B Hube, BN Gantner, C Jiménez-López, C Sasse, C Tokarski, CC Sheth, CF Urban, CGJ McKenzie, CJ Chrisman, D Armstrong-James, D Ermert, D Liebl, D Vijayan, DA Silva da, DC Savage, DJ Krysan, E Moreno-Ruiz, EK Szabo, FM Rudkin, G Chamilos, G Vande Velde, GD Brown, GD Brown, H Ma, H Ma, I Rubin-Bejerano, IE Frohner, J Behnsen, J Chandra, J Maertens, J Perlroth, J Voigt, JM Bain, JM Tam, Judith Bain, K Konig, K Schäfer, K Seider, KM Brothers, L Romani, L Romani, Lars-Peter Erwig, LE Lewis, LE Lewis, LG Tilney, LY Ngo, M Alvarez, MC Lorenz, MG Netea, MJ Patterson, MS Lionakis, MS Lionakis, N Papon, NAR Gow, Neil A. R. Gow, O Uzun, O Zaragoza, P Martino, P Miramón, Q Qian, R García-Rodas, RA Drummond, RD Diamond, RI Lehrer, S Bruns, S El-Kirat-Chatel, S Keppler-Ross, S Mitra, SA Johnston, SC Cheng, SE Heinsbroek, V Aimanianda, Wellington, Y Luo   +77 more
core   +1 more source

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis

Nature, 2016
Atherosclerosis is the disease process that underlies heart attack and stroke. Advanced lesions at risk of rupture are characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris.
Y. Kojima, J. Volkmer, K. McKenna, M. Civelek, A. Lusis, Clint L. Miller, Daniel Direnzo, Vivek Nanda, Jianqin Ye, A. Connolly, E. Schadt, T. Quertermous, Paola A. Betancur, L. Maegdefessel, L. Matic, U. Hedin, I. Weissman, N. Leeper   +17 more
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Induction of Live Cell Phagocytosis by a Specific Combination of Inflammatory Stimuli

EBioMedicine, 2017
Conditions of severe hyper-inflammation can lead to uncontrolled activation of macrophages, and the ensuing phagocytosis of live cells. However, relationships between inflammatory stimuli and uncontrolled phagocytosis of live cells by macrophages are ...
Takamasa Ishidome, Takeshi Yoshida, Rikinari Hanayama   +2 more
doaj   +1 more source

Influenza-Specific Antibody-Dependent Phagocytosis. [PDF]

PLoS ONE, 2016
Immunity to human influenza A virus (IAV) infection is only partially understood. Broadly non-neutralizing antibodies may assist in reducing disease but have not been well characterized.We measured internalization of opsonized, influenza protein-coated ...
Fernanda Ana-Sosa-Batiz, Hillary Vanderven, Sinthujan Jegaskanda, Angus Johnston, Steven Rockman, Karen Laurie, Ian Barr, Patrick Reading, Marit Lichtfuss, Stephen J Kent   +9 more
doaj   +1 more source

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation [PDF]

, 2010
The lysis of infected cells by disease-causing microorganisms is an efficient but risky strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the host's immune system.
A Casadevall, A Drengk, A Pendleton, AE Brouwer, BJ Park, C Charlier, D Liebl, E Groves, H Ma, H Ma, HD Ochs, J Pieters, J Pizarro-Cerda, J Riedl, JL Gaillard, JM Stevens, JP Grabenstein, JR Peterson, K Hybiske, LG Tilney, LR Prost, M Alvarez, M Clarke, M Desjardins, M Hagedorn, M Shi, NE Freitag, NR Jog, PT Yam, R Rohatgi, RC May, RH Insall, Robin C. May, SC Tucker, Simon A. Johnston, Stuart M. Levitz, TA Lyubchenko   +36 more
core   +4 more sources

LC3-associated phagocytosis [PDF]

Autophagy, 2014
A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes
Romao Susana, Münz Christian
openaire   +4 more sources

Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation

Advanced Healthcare Materials, EarlyView.
Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara, Emma R. Brannon, Daniel Kupor, Mariana R.N. Lima, Logan D. Piegols, Michael L. Felder, Kathryn E. Uhrich, Omolola Eniola‐Adefeso   +7 more
wiley   +1 more source

Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality

Advanced Healthcare Materials, EarlyView.
The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic, Isabella Åberg, Omar Omar, Håkan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen, Furqan A. Shah   +7 more
wiley   +1 more source