Results 121 to 130 of about 202,252 (310)
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu+10 more
wiley +1 more source
The aggregation‐induced emission luminogens (AIEgens) propel the development of drug and gene delivery systems. The lit‐up AIEgens first serve for real‐time monitoring of the delivery processes and evaluation of therapeutic responses of drug/gene. The delicate design of AIEgens to form high‐level structural carrier remarkably enhances the delivery ...
Jie Sun, Xuewen He
wiley +1 more source
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai+12 more
wiley +1 more source
THE RELATIONSHIP OF M PROTEIN AND RESISTANCE TO PHAGOCYTOSIS IN THE BETA HEMOLYTIC STREPTOCOCCI [PDF]
Myron Morris, C. V. Seastone
openalex +1 more source
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du+8 more
wiley +1 more source
An experimental enquiry into the nature of the substance in serum which influences phagocytosis [PDF]
George Dean
openalex +1 more source
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu+12 more
wiley +1 more source
Abstract Direct comparisons of the effectiveness of the numerous novel therapies in the diffuse large B‐cell lymphoma (DLBCL) treatment landscape in a range of head‐to‐head randomized phase 3 trials would be time‐consuming and costly. Comparative effectiveness studies using real‐world data (RWD) represent a complementary approach.
Grzegorz Nowakowski+4 more
wiley +1 more source
Phagocytosis in the Postembryonic Development of the Diptera [PDF]
Vernon L. Kellogg
openalex +1 more source
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan+11 more
wiley +1 more source