Results 341 to 350 of about 420,323 (395)

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes-Brief Report. [PDF]

Arterioscler Thromb Vasc Biol
Yagi H, Boeck M, Neilsen K, Yang J, Ko M, Tomita Y, Negishi K, Fu Z, Sun Y, Smith LEH.   +9 more
europepmc   +1 more source

Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice

Glia, EarlyView.
ABSTRACT Spinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation,
Barbora Smejkalová, Marta Ornaghi, Kateřina Štěpánková, Juliane Schiweck, Lucia Machová Urdzíková, Robert Huelse, Susanne Mueller, Philipp Boehm‐Sturm, Jessica C. F. Kwok, James Fawcett, Kai Murk, Britta J. Eickholt, Pavla Jendelová   +12 more
wiley   +1 more source

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
Jiang M, Li Q, Chen J, Li R, Yao J, Hu Y, Zhang H, Cai L, Luo M, Sun Y, Zeng W.   +10 more
europepmc   +1 more source

Pretreatment Neutrophil‐to‐Lymphocyte Ratio (NLR) Predicts Treatment Toxicity and Intolerance in Operable Head and Neck Cancer: An Ambispective Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background Pretreatment neutrophil to lymphocyte ratio (NLR) is a negative prognostic marker for survival in head and neck cancer (HNC). Its association with treatment toxicity and intolerance in patients undergoing curative‐intent surgery is unknown. Methods Ambispective study of patients with operable stage II–IV, HPV‐negative HNC treated at
Raisa Chowdhury, Karim Botros, Keith Richardson, Alex M. Mlynarek, Nader Sadeghi, Michael P. Hier, Sabrina Wurzba, Khashayar Esfahani, Nathaniel Bouganim, Khalil Sultanem, George Shenouda, Christina Tsien, Marco A. Mascarella   +12 more
wiley   +1 more source

Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24. [PDF]

J Immunother Cancer
Liu Y, Ma J, Ma Y, Wang BZ, Wang Y, Yuan J, Zhang F, Zhao X, Chen K, Zhang X, Wang H.   +10 more
europepmc   +1 more source

Bioinformatics Approach to Identifying Molecular Targets of Isoliquiritigenin Affecting Chronic Obstructive Pulmonary Disease: A Machine Learning Pharmacology Study. [PDF]

Int J Mol Sci
Huang S, Zhang L, Liu X.
europepmc   +1 more source

Oncolytic viruses targeting CD47: a new road to success? [PDF]

J Immunother Cancer
Takimoto CH, Wick MJ.
europepmc   +1 more source

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

An in vivo study of the ameliorative effect of supplementation with Lacticaseibacillus paracasei Glory LP16 in immunocompromised mice. [PDF]

Sci Rep
Ma W, Wu Y, Sun H, Zhao Y, Huang L.
europepmc   +1 more source