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2022
One hundred years have passed since the death of Élie Metchnikoff (1845-1916). He was the first to observe the uptake of particles by cells and realized the importance of this process, named phagocytosis, for the host response to injury and infection. He also was a strong advocate of the role of phagocytosis in cellular immunity, and with this, he gave
Eileen, Uribe-Querol, Carlos, Rosales
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One hundred years have passed since the death of Élie Metchnikoff (1845-1916). He was the first to observe the uptake of particles by cells and realized the importance of this process, named phagocytosis, for the host response to injury and infection. He also was a strong advocate of the role of phagocytosis in cellular immunity, and with this, he gave
Eileen, Uribe-Querol, Carlos, Rosales
openaire +2 more sources
Mechanisms of phagocytosis in macrophages.
Annual Review of Immunology, 1999Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic ...
A. Aderem, D. Underhill
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BioEssays, 1995
AbstractPhagocytosis is the process of recognition and engulfment of microorganisms or tissue debris that accumulate during infection, inflammation or wound repair. This ingestion, which is performed most efficiently by migrating, bone marrow‐derived cells called ‘professional phagocytes’, is essential for successful host defense.
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AbstractPhagocytosis is the process of recognition and engulfment of microorganisms or tissue debris that accumulate during infection, inflammation or wound repair. This ingestion, which is performed most efficiently by migrating, bone marrow‐derived cells called ‘professional phagocytes’, is essential for successful host defense.
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Specialization in phagocytosis
Journal of Theoretical Biology, 1976Abstract When phagocytes have been incubated with a mixture of two types of particles (say A and B), a microscopic count can be made of cells having ingested i A-particles and j B-particles, for various i and j. Simple assumptions (the validity of which has been checked in a previous work) allow derivation of formulae that give a fair account of ...
Pierre Bongrand +3 more
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Microbes and Infection, 2003
Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation
Rene E. Harrison +2 more
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Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation
Rene E. Harrison +2 more
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CRC Critical Reviews in Toxicology, 1978
Primitive unicellular organisms depend greatly on internalization of particulate matter for nourishment. In metazoa, this process is further developed to play a major role in mechanisms of defense. This review analyzes, mainly in mammalian systems, the various phenomena surrounding the phagocytic act. Much of the emphasis is placed on experimental work
M. N.-I. Walters +2 more
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Primitive unicellular organisms depend greatly on internalization of particulate matter for nourishment. In metazoa, this process is further developed to play a major role in mechanisms of defense. This review analyzes, mainly in mammalian systems, the various phenomena surrounding the phagocytic act. Much of the emphasis is placed on experimental work
M. N.-I. Walters +2 more
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Endocrinology, 1955
AS HAS been pointed out by Thomas (1952, 1953), cortisone has been L demonstrated to reduce the resistance of mammals to bacteria, viruses, fungi, and bacterial toxins. In discussing the various methods whereby cortisone might act to produce these results, the author suggests the conclusion that the effect must be on the reticuloendothelial system (RES)
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AS HAS been pointed out by Thomas (1952, 1953), cortisone has been L demonstrated to reduce the resistance of mammals to bacteria, viruses, fungi, and bacterial toxins. In discussing the various methods whereby cortisone might act to produce these results, the author suggests the conclusion that the effect must be on the reticuloendothelial system (RES)
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