Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
Cells, 2019 Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses.
Ming-Yue Wu, Jiahong Lu
semanticscholar +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD
Respiratory Research, 2021 Background Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline.
R. Singh +8 more
doaj +1 more source
Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. [PDF]
, 2004 Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor ...
Brodie, Scott E +5 more
core +1 more source
Role of target geometry in phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America, 2006 Phagocytosis is a principal component of the body's innate immunity in which macrophages internalize targets in an actin-dependent manner. Targets vary widely in shape and size and include particles such as pathogens and senescent cells.
J. Champion, S. Mitragotri
semanticscholar +1 more source
Genomic landscape and preclinical models of angiosarcoma
Molecular Oncology, EarlyView.Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton +3 more
wiley +1 more source
PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway
Immunity, Inflammation and Disease, 2022 Prostaglandin E2 (PGE2) is a potent lipid mediator of inflammation that modulates immune cell function by binding to unique G protein‐coupled receptors (EP receptors). PGE2 production increases during microbial infection and inflammation.
Zixuan Wang +5 more
doaj +1 more source
The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes. [PDF]
, 1989 Phagosomes were purified from human neutrophils ingesting Salmonella typhimurium opsonized with adsorbed normal human serum or with rabbit IgG. Constituents within the phagosome were endogenously labeled by supplying the cells with 125INa during ...
Albert, J +3 more
core
A Fully Unsupervised Instance Segmentation Technique for White Blood Cell Images [PDF]
arXiv, 2023 White blood cells, also known as leukocytes are group of heterogeneously nucleated cells which act as salient immune system cells. These are originated in the bone marrow and are found in blood, plasma, and lymph tissues. Leukocytes kill the bacteria, virus and other kind of pathogens which invade human body through phagocytosis that in turn results ...
arxiv
Phagocytosis: A Fundamental Process in Immunity
BioMed Research International, 2017 One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was the first to observe the uptake of particles by cells and realized the importance of this process for the host response to injury and infection.
C. Rosales, E. Uribe-Querol
semanticscholar +1 more source