Results 81 to 90 of about 442,934 (391)

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis

Nature, 2016
Atherosclerosis is the disease process that underlies heart attack and stroke. Advanced lesions at risk of rupture are characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris.
Y. Kojima, J. Volkmer, K. McKenna, M. Civelek, A. Lusis, Clint L. Miller, Daniel Direnzo, Vivek Nanda, Jianqin Ye, A. Connolly, E. Schadt, T. Quertermous, Paola A. Betancur, L. Maegdefessel, L. Matic, U. Hedin, I. Weissman, N. Leeper   +17 more
semanticscholar   +1 more source

15-Epi-LXA4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes, followed by neutrophil apoptosis and removal by macrophages. Neutrophils integrate cues from the
Meriem Sekheri, D. El Kebir, Natalie Edner, J. Filep   +3 more
semanticscholar   +1 more source

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source

PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway

Immunity, Inflammation and Disease, 2022
Prostaglandin E2 (PGE2) is a potent lipid mediator of inflammation that modulates immune cell function by binding to unique G protein‐coupled receptors (EP receptors). PGE2 production increases during microbial infection and inflammation.
Zixuan Wang, Xinyuan Wei, Caili Ji, Wenhua Yu, Chuanwang Song, Caizhi Wang   +5 more
doaj   +1 more source

Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis [PDF]

, 2017
Acknowledgements: The authors would like to acknowledge Fraser P. Coxon and Ian Ganley for providing LC3-GFP-mCherry BMDMs. M.S.G. was supported by an FEMS research grant and F.L.v.d.V.
Alonso, M Fernanda, Bain, Judith M, Becker, Katharina L, Erwig, Lars P, Gresnigt, Mark S, Leenders, Floris, Meis, Jacques F, van de Veerdonk, Frank L, Wang, Xiaowen   +8 more
core   +2 more sources

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation?

Advanced Biology, EarlyView.
The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma, Femmy C. Stempels, Rinse de Boer, Geert van den Bogaart   +3 more
wiley   +1 more source

Galectin-3 (MAC-2) Controls Microglia Phenotype Whether Amoeboid and Phagocytic or Branched and Non-phagocytic by Regulating the Cytoskeleton

Frontiers in Cellular Neuroscience, 2019
Myelin surrounding central nervous system (CNS) axons breaks down in multiple sclerosis (MS) and following traumatic axonal injury. Myelin-debris so produced is harmful to repair since it impedes remyelination in MS and the regeneration of traumatized ...
Fanny Reichert, Shlomo Rotshenker
doaj   +1 more source

Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction [PDF]

, 2015
Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology.
Bain, Judith M, Erwig, Lars-Peter, Gow, Neil A R, Lyall, Natalie, Okai, Blessing   +4 more
core   +2 more sources

Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin‐Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice

Advanced Biology, EarlyView.
This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves, Maria Poliana Leite Galantini, Igor Pereira Ribeiro Muniz, Paulo Henrique Bispo Lima, Israel Souza Ribeiro, Maria Eduarda Santos de Oliveira, Caio Oliveira Lopes de Magalhães, Maria Elisa Santos Flores, Samara Lopes de Oliveira, Catarina Silva Guimarães, Paulinne Moreira Lima, Luísa Carregosa Santos, Daiana Silva Lopes, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva   +14 more
wiley   +1 more source

Modulation (Inhibition and Augmentation) of Complement Receptor-3-Mediated Myelin Phagocytosis

Neurobiology of Disease, 2001
The removal of damaged myelin is central to repair after injury to axons and in autoimmune demyelinating diseases. Complement receptor 3 (CR3/MAC-1) plays a major role in mediating the phagocytosis of damaged myelin by macrophages and microglia.
Fanny Reichert, Uri Slobodov, Chen Makranz, Shlomo Rotshenker   +3 more
doaj   +1 more source